{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:51:30Z","timestamp":1791352290442,"version":"4.3.1"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230085"],"award-info":[{"award-number":["82230085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272572"],"award-info":[{"award-number":["82272572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ60682"],"award-info":[{"award-number":["2025JJ60682"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Rotator cuff injury (RCI) is frequently accompanied by psychological comorbidities, particularly anxiety\u2010related symptoms, which predict poor functional recovery, yet the central mechanisms linking affective disturbance to impaired tendon\u2013bone healing remain unclear. Here, by integrating clinical neuroimaging, imaging transcriptomics, and mechanistic animal experiments, we identify hypothalamic paraventricular nucleus (PVN) oxytocinergic (OXT) neurons as a critical central node coordinating emotional regulation and bone\u2013tendon interface (BTI) repair. In patients with RCI, resting\u2010state fMRI (rs\u2010fMRI) revealed reduced hypothalamic spontaneous activity that was inversely correlated with anxiety severity. Imaging transcriptomic analyses further linked these functional alterations to spatially concordant gene expression programs enriched in oxytocin signaling. In mouse models, retrograde viral tracing and spatial transcriptomics identified PVN\n                    <jats:sup>OXT<\/jats:sup>\n                    neurons as the predominant labeled population within a polysynaptic PVN\u2013IML\u2013SCG sympathetic pathway connected to the subchondral bone region of the rotator cuff enthesis. In vivo local field potential recordings confirmed a reduction in PVN neuronal activity that peaked at four weeks post\u2010injury and recovered thereafter, paralleling the behavioral time course. Chemogenetic inhibition of PVN\n                    <jats:sup>OXT<\/jats:sup>\n                    neurons induced anxiety\u2010like behaviors and impaired BTI healing, whereas their activation alleviated anxiety and enhanced structural and biomechanical recovery. Together, these findings support a working model in which a PVN\n                    <jats:sup>OXT\u2013<\/jats:sup>\n                    sympathetic\u2010shoulder axis links anxiety dysregulation to musculoskeletal healing through a hypothalamic\u2013sympathetic pathway, providing a framework for integrated neuromodulatory and tissue\u2010targeted interventions in RCI.\n                  <\/jats:p>","DOI":"10.1002\/advs.78190","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:36:21Z","timestamp":1791351381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Hypothalamic Oxytocinergic\u2013Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon\u2013Bone Repair"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-1080","authenticated-orcid":false,"given":"Liyang","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Sports Medicine, Xiangya Hospital Central South University  Changsha China"},{"name":"Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2644-0429","authenticated-orcid":false,"given":"Tingmo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Xiangya Hospital Central South University  Changsha China"},{"name":"Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyue","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Xiangya Hospital Central South University  Changsha China"},{"name":"Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3555-9153","authenticated-orcid":false,"given":"Ruixue","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Xiangya Hospital Central South University  Changsha China"},{"name":"Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha 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Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Xiangya Hospital Central South University  Changsha China"},{"name":"Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Organ Injury Aging and Regenerative Medicine of Hunan Province  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University  Changsha China"},{"name":"Department of Orthopaedics Xiangya Hospital Central South University  Changsha 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