{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:55Z","timestamp":1791352255791,"version":"4.3.1"},"reference-count":56,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two\u2010dimensional (2D) metallic nanosheets are promising for neural implants, but their application is hindered by limited lateral dimensions, poor mechanical compliance, and insufficient electrochemical stability. Here, we report a wafer\u2010scale wet\u2010chemical synthesis of an ultrathin, intrinsically porous dendritic platinum (Pt) film (\n                    <jats:italic>\n                      den\u20102DPt\n                      <jats:sub>waf<\/jats:sub>\n                    <\/jats:italic>\n                    ) that can be transferred onto flexible substrates for robust neural interfacing. Confined Pt growth on a layered double hydroxide (LDH)\u2010modified Si wafer produces a wafer\u2010sized, 6\u2010nm\u2010thick film that is vertically conductive but laterally insulating. As a bioelectrode (area = 4 \u00d7 10\n                    <jats:sup>\u22124<\/jats:sup>\n                    cm\n                    <jats:sup>2<\/jats:sup>\n                    ),\n                    <jats:italic>\n                      den\u20102DPt\n                      <jats:sub>waf<\/jats:sub>\n                    <\/jats:italic>\n                    exhibits low impedance (\u223c45 \u03a9 at 1\u00a0kHz), high charge storage capacity (\u223c12 mC cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ), and high charge injection capacity (1.13 mC cm\n                    <jats:sup>\u22122<\/jats:sup>\n                    ). It also maintains its performance after &gt;10,000 bending cycles at a 2\u2010mm radius and under accelerated oxidative conditions (3% H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ), outperforming conventional flat Pt films. In vivo,\n                    <jats:italic>\n                      den\u20102DPt\n                      <jats:sub>waf<\/jats:sub>\n                    <\/jats:italic>\n                    electrodes enable effective vagus nerve stimulation, inducing immediate, current\u2010dependent reductions in rat breathing rate while maintaining stable activation thresholds and electrochemical and structural integrity over two weeks. This scalable porous Pt film provides a mechanically compliant and electrochemically resilient platform for long\u2010term neural recording and stimulation.\n                  <\/jats:p>","DOI":"10.1002\/advs.78193","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:18:47Z","timestamp":1791350327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Wafer\u2010Scale Dendritic Nanoporous Platinum Films for Neural Electrodes"],"prefix":"10.1002","author":[{"given":"Kyeongbin","family":"Kang","sequence":"first","affiliation":[{"name":"Center For Nanospace\u2010confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH)  Pohang South Korea"},{"name":"Division of Advanced Materials Science Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2891-7967","authenticated-orcid":false,"given":"Joosung","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1465-2723","authenticated-orcid":false,"given":"Soumen","family":"Dutta","sequence":"additional","affiliation":[{"name":"Center For Nanospace\u2010confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH)  Pohang South Korea"},{"name":"Department of Chemistry Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Woo","family":"Jang","sequence":"additional","affiliation":[{"name":"Center For Nanospace\u2010confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH)  Pohang South Korea"},{"name":"Department of Chemistry Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6974-2746","authenticated-orcid":false,"given":"Byeong Su","family":"Gu","sequence":"additional","affiliation":[{"name":"Center For Nanospace\u2010confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH)  Pohang South Korea"},{"name":"Department of Chemistry Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8669-2082","authenticated-orcid":false,"given":"Woosung","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2115-0126","authenticated-orcid":false,"given":"Sunguk","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4325-2518","authenticated-orcid":false,"given":"Seongjae","family":"Lee","sequence":"additional","affiliation":[{"name":"Major of Medical Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2513-6275","authenticated-orcid":false,"given":"Hyo Kyoung","family":"Jeon","sequence":"additional","affiliation":[{"name":"AX Graduate School Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1681-3230","authenticated-orcid":false,"given":"Juwan","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-901X","authenticated-orcid":false,"given":"Keehoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-8110","authenticated-orcid":false,"given":"Sung\u2010Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"},{"name":"Major of Medical Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-7595","authenticated-orcid":false,"given":"Unyong","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2588-1444","authenticated-orcid":false,"given":"In Su","family":"Lee","sequence":"additional","affiliation":[{"name":"Center For Nanospace\u2010confined Chemical Reactions (NCCR) Pohang University of Science and Technology (POSTECH)  Pohang South Korea"},{"name":"Division of Advanced Materials Science Pohang University of Science and Technology (POSTECH)  Pohang South Korea"},{"name":"Department of Chemistry Pohang University of Science and Technology (POSTECH)  Pohang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"6225","DOI":"10.1021\/acs.chemrev.6b00558","article-title":"Recent Advances in Ultrathin Two\u2010Dimensional Nanomaterials","volume":"117","author":"Tan C.","year":"2017","journal-title":"Chemical Reviews"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00236A"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.1589"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1021\/acs.accounts.8b00491","article-title":"Wearable and Implantable Soft Bioelectronics Using Two\u2010Dimensional Materials","volume":"52","author":"Choi C.","year":"2019","journal-title":"Accounts of Chemical Research"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0EE01714K"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202312656"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1039\/C9MH01142K","article-title":"A Centimeter Scale Self\u2010Standing Two\u2010Dimensional Ultra\u2010Thin Mesoporous Platinum Nanosheet","volume":"7","author":"Li Y.","year":"2020","journal-title":"Materials Horizons"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544\u2010017\u20100201\u20104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"10431","DOI":"10.1021\/acsnano.2c00880","article-title":"Facile and Scalable Synthesis of Whiskered Gold Nanosheets for Stretchable, Conductive, and Biocompatible Nanocomposites","volume":"16","author":"Lim C.","year":"2022","journal-title":"ACS Nano"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41596\u2010020\u20100389\u20102"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"8632","DOI":"10.1039\/D4CS00413B","article-title":"Bioelectronics for Electrical Stimulation: Materials, Devices and Biomedical Applications","volume":"53","author":"Huang Y.","year":"2024","journal-title":"Chemical Society Reviews"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.152861"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1146\/annurev.bioeng.10.061807.160518","article-title":"Neural Stimulation and Recording Electrodes","volume":"10","author":"Cogan S. F.","year":"2008","journal-title":"Annual Review of Biomedical E4ngineering"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34906"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.snb.2018.08.007"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"5068","DOI":"10.1021\/acs.chemrev.1c00531","article-title":"Soft Bioelectronics Based on Nanomaterials","volume":"122","author":"Cho K. W.","year":"2022","journal-title":"Chemical Reviews"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR06280H"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741\u20102552\/ab2e79"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1038\/s41598-024-53719-4","article-title":"Flexible Metallic Core\u2013Shell Nanostructured Electrodes for Neural Interfacing","volume":"14","author":"Rodilla B. L.","year":"2024","journal-title":"Scientific Reports"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","unstructured":"M.Patan T.Shah andM.Sahin \u201cCharge Injection Capacity of TiN Electrodes for an Extended Voltage Range \u201d in2006 International Conference of the IEEE Engineering in Medicine and Biology Society(IEEE 2006) 890\u2013892 https:\/\/doi.org\/10.1109\/IEMBS.2006.260088.","DOI":"10.1109\/IEMBS.2006.260088"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2005.851503"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/admi.202000675"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2004.10.020"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/1741\u20102552\/abb9bf"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/admt.202200143"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202208881"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.6b13468"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.05.004"},{"key":"e_1_2_10_30_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2020.112645","article-title":"Micro\u2010 and Nanotechnology for Neural Electrode\u2010Tissue Interfaces","volume":"170","author":"Liu S.","year":"2020","journal-title":"Biosensors and Bioelectronics"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13162834"},{"key":"e_1_2_10_32_1","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1021\/acs.accounts.4c00163","article-title":"Soft Bioelectronics Using Nanomaterials and Nanostructures for Neuroengineering","volume":"57","author":"Kim M.","year":"2024","journal-title":"Accounts of Chemical Research"},{"key":"e_1_2_10_33_1","doi-asserted-by":"crossref","first-page":"7550","DOI":"10.1021\/acsnano.2c12659","article-title":"Stretchable Low\u2010Impedance Conductor with Ag\u2013Au\u2013Pt Core\u2013Shell\u2013Shell Nanowires and in Situ Formed Pt Nanoparticles for Wearable and Implantable Device","volume":"17","author":"Sunwoo S.\u2010H.","year":"2023","journal-title":"ACS Nano"},{"key":"e_1_2_10_34_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202402214","article-title":"Stretchable Tissue\u2010Like Gold Nanowire Composites with Long\u2010Term Stability for Neural Interfaces","volume":"20","author":"Seufert L.","year":"2024","journal-title":"Small"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18030"},{"key":"e_1_2_10_36_1","doi-asserted-by":"crossref","first-page":"6409","DOI":"10.1021\/acs.chemrev.7b00727","article-title":"Two\u2010Dimensional Metal Nanomaterials: Synthesis, Properties, and Applications","volume":"118","author":"Chen Y.","year":"2018","journal-title":"Chemical Reviews"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR01807A"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c01589"},{"key":"e_1_2_10_39_1","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.1002\/adma.201501403","article-title":"Freestanding Ultrathin Metallic Nanosheets: Materials, Synthesis, and Applications","volume":"27","author":"Ling T.","year":"2015","journal-title":"Advanced Materials"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.0c04628"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2008.03.016"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0sc04196c"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja037474t"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1CS00706H"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c01000"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c06367"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp911256h"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.07.036"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0153094"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c03977"},{"key":"e_1_2_10_51_1","doi-asserted-by":"crossref","unstructured":"C. A.KuliashaandJ. W.Judy \u201cIn Vitro Reactive\u2010Accelerated\u2010Aging (RAA) Assessment of Tissue\u2010Engineered Electronic Nerve Interfaces (TEENI) \u201d in2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)(IEEE 2018) 5061\u20135064.","DOI":"10.1109\/EMBC.2018.8513458"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.09.002"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja804397n"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202516217"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2008.06.001"},{"key":"e_1_2_10_56_1","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202006612","article-title":"Printed Stretchable Liquid Metal Electrode Arrays for In Vivo Neural Recording","volume":"17","author":"Dong R.","year":"2021","journal-title":"Small"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNSRE.2025.3643813"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:18:51Z","timestamp":1791350331000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":56,"alternative-id":["10.1002\/advs.78193"],"URL":"https:\/\/doi.org\/10.1002\/advs.78193","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]},"assertion":[{"value":"2026-06-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78193"}}