{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:45:48Z","timestamp":1791780348332,"version":"4.3.4"},"reference-count":155,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hydrophilic biomacromolecules, including insulin, peptides, proteins and vaccine antigens, have transformed modern therapeutics, yet their delivery remains dominated by injections because the stratum corneum (SC) severely restricts passive transport of large and polar molecules. Microneedles have created a route through this barrier, but many existing systems remain limited by low loading capacity, burst release, weak dose control, microbiological quality requirements, short\u2010term stability, and poor manufacturing scalability. This review critically examines hydrogel\u2010forming microneedle (HFMN)\u2010reservoir patches as an emerging architecture for controlled transdermal biomacromolecule delivery. Rather than treating microneedles as isolated projections, it positions the patch as an integrated multilayer device comprising a skin\u2010interfacing hydrogel conduit, a drug reservoir, a diffusion\u2010control layer, and a protective backing. Particular emphasis is placed on sustainable polymers, including cellulose derivatives, alginate, chitosan (CS), polyethylene oxide (PEO), carboxymethyl chitosan (CMCS) and oxidized polysaccharides, together with scalable manufacturing routes such as pressurized gyration (PG). The review also evaluates fluorescein isothiocyanate (FITC)\u2010dextran and other model macromolecules, highlighting what they prove about physical transport and what they cannot prove about therapeutic bioactivity. Finally, design rules are proposed for next\u2010generation microneedle\u2010reservoir patches that integrate biomaterial selection, release control, green manufacturing, and translational requirements.<\/jats:p>","DOI":"10.1002\/advs.78195","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:04:31Z","timestamp":1791777871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustainable Hydrogel\u2010Forming Microneedle\u2010Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation"],"prefix":"10.1002","author":[{"given":"Siddharth","family":"Mohanty","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering University College London (UCL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-3856","authenticated-orcid":false,"given":"Mehmet Onur","family":"Aydogdu","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University College London (UCL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University College London (UCL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University College London (UCL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-7914","authenticated-orcid":false,"given":"Mohan","family":"Edirisinghe","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering University College London (UCL)  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010020\u201002844\u20106"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010021\u201001077\u20103"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573\u2010023\u201000670\u20100"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010025\u201004117\u20108"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2018.1534113"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2023.2296350"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics7040438"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2017.06.019"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmm2.70001"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c00211"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010025\u201006219\u20106"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16010057"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010024\u201003029\u20109"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.10.023"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde\u20102017\u20100028"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.02.011"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.078"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.11.056"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2026.2642108"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120455"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111547"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202001256"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202000307"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels9100806"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412140"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics7030090"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2018.1539497"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/jpps.2024.12434"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201200864"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.02.031"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0TB00021C"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11110605"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121593"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010019\u201000671\u2010w"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010018\u20100337\u20104"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201905740"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14051097"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.06.029"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.02.127"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.125128"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c01261"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2015.04.008"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/mi9010040"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.03.005"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010277"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202203274"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202101210"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102712"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120303"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.11.025"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201019463\u20102"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.12.184"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2021.04.024"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300576"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11082119"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121835"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010016\u20100328\u20105"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10110719"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201500016"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2025.114936"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010015\u20100237\u2010z"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2003.12.010"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16111480"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00844"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119580"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113018"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124768"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reactfunctpolym.2022.105200"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010022\u201004473\u20101"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.07.087"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.07.001"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2020.1742144"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303326"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202408657"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201702243"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.2c01297"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2017.04.017"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10070"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.09.161"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213659"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103668"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2022.2155778"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tec.2022.0045"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10544\u2010019\u20100449\u2010y"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010018\u20101673\u2010y"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13203455"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v6i5.1275"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.4c08259"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtla.2020.100649"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29112515"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/app.46911"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2023.2230847"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NR01742C"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212871"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671\u2010018\u20102491\u20108"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.202400228"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202507209"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1GC04252A"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15020579"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.123972"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/macromol4020019"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.041"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125932"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1590\/s2175\u201097902022e20802"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.1c00013"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201700577"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201800577"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202300033"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0244921"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2025.126331"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apenergy.2026.128062"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.125061"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/09205063.2022.2157671"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1611"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/marc.201300339"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.201600564"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2024.2415482"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2023.110701"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1177\/0885328215613886"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.03.036"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.3390\/fib6030045"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/mame.202100891"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.114904"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2015.06.021"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.35869"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122885"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph18020158"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.4c18381"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2TB01049F"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010023\u201003529\u20106"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01306"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.8b00441"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118211"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2015.05.002"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10570\u2010024\u201005793\u20100"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201036009\u20108"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsapm.3c01293"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2017.04.029"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c00499"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c00492"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249\u2010018\u20100959\u20106"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.122692"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306560"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309027"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010016\u20100282\u20102"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2024.114415"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12070606"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels10040260"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.11.021"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/agt2.700"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202409519"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010019\u201000620\u20107"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201011678\u20108"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202304124"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44286\u2010024\u201000128\u2010z"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:04:33Z","timestamp":1791777873000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,11]]},"references-count":155,"alternative-id":["10.1002\/advs.78195"],"URL":"https:\/\/doi.org\/10.1002\/advs.78195","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,11]]},"assertion":[{"value":"2026-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78195"}}