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Metasensors can amplify these vibrational signals through local near\u2010field enhancement. However, current THz molecular fingerprint metasensors lack a systematic design and optimization methodology, which severely limits their potential. Here, we unveil the crucial role of resonant loss rate in THz molecular fingerprint sensing and present a loss\u2010engineering\u00a0methodology for optimized molecular vibrational sensing. Based on the proposed methodology, we experimentally demonstrate a 12.6\u2010fold enhancement of the molecular fingerprint signal with three\u2010dimensionally printed pixelated metasensors. \u00a0Furthermore, the pixelated metasensors support vibrational strong\u2010coupling, providing a unified platform for enhanced molecular sensing and strong light\u2010matter interaction. Overall, the proposed metasensor could bridge THz molecular vibrational fingerprint sensing to end\u2010use applications in label\u2010free chemical and biomedical detection.<\/jats:p>","DOI":"10.1002\/advs.78233","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:10:37Z","timestamp":1792033837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss\u2010Engineered Terahertz Pixelated Metasensors for Enhanced Molecular Vibrational Fingerprint Sensing"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2987-9931","authenticated-orcid":false,"given":"Chenglin","family":"Yang","sequence":"first","affiliation":[{"name":"School of Mechanical Engineering Xi'an Jiaotong University  Xi'an Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Mechanical 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