{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:52:05Z","timestamp":1792036325098,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82325050"],"award-info":[{"award-number":["82325050"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC3512500"],"award-info":[{"award-number":["2025YFC3512500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    STING undergoes distinct post\u2010translational modifications in autoimmune disorders, particularly in psoriasis. However, selectively targeting these disease\u2010associated STING modifications remains a major therapeutic challenge. Here, we show that macrophage STING\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAcylation is a critical driver of psoriatic inflammation and identify the natural small\u2010molecule paeoniflorin (PF) as a selective inhibitor of STING\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAcylation. Mechanistically, PF engages the cyclic dinucleotide\u2010binding domain (CBD) of STING, inducing an allosteric conformational shift that traps STING in an inactive open state. This allosteric mechanism sterically blocks\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAc transferase (OGT) recruitment to STING, thereby suppressing STING\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAcylation and subsequent TBK1\u2010dependent phosphorylation cascades. In vivo, PF markedly alleviates psoriatic skin inflammation, whereas myeloid\u2010specific STING ablation substantially compromises its therapeutic efficacy. Critically, clinical analyses of patient\u2010derived samples further support the relevance of STING\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAcylation to psoriasis. Together, our work uncovers macrophage STING\n                    <jats:italic>O<\/jats:italic>\n                    \u2010GlcNAcylation as a critical regulatory checkpoint in psoriatic inflammation, highlighting a promising natural product\u2010based strategy for targeting pathological STING signaling.\n                  <\/jats:p>","DOI":"10.1002\/advs.78257","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:37:27Z","timestamp":1792035447000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Macrophage STING\n                    <i>O<\/i>\n                    \u2010GlcNAcylation via Small\u2010Molecule Allosteric Modulation for Psoriasis Therapy"],"prefix":"10.1002","author":[{"given":"Fang\u2010Fang","family":"Zhuo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Chen","family":"Hou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Xuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan\u2010Jian","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010Fei","family":"Tu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical Sciences Peking University  Beijing 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Sciences Peking University  Beijing China"},{"name":"Department of Integrated Traditional Chinese and Western Medicine Peking University First Hospital  Beijing 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