{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:51:19Z","timestamp":1792036279411,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82672504"],"award-info":[{"award-number":["82672504"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901807"],"award-info":[{"award-number":["81901807"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102063"],"award-info":[{"award-number":["82102063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatic ischemia\u2012reperfusion injury (HIRI) critically compromises liver surgery and transplantation outcomes. Its pathogenesis centers on mitochondrial dysfunction\u2010driven oxidative stress and sterile inflammation. However, current therapies lack lesion\u2010specific targeting, fail to suppress ROS generation at the mitochondrial source, and lack integrated theranostic capabilities such as cascade antioxidant activity, anti\u2010inflammatory effects, and real\u2010time imaging. To address these limitations, we developed FeCD\u2010SS31, an integrated nanoplatform composed of a mesoporous Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    core conjugated with glutathione\/biotin\u2010derived carbon dots (CDs) and linked to the mitochondrial\u2010targeting peptide SS31 through an ROS\u2010responsive bond. The system enabled hepatic mitochondrial targeting and responsive SS31 release, restoring mitochondrial complex integrity to suppress de novo ROS generation. Meanwhile, the Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    \/CDs core exerted cascade enzymatic activities to scavenge existing ROS, achieving dual\u2010axis oxidative stress inhibition. This synergy blocked the caspase\u20101\u2013GSDMD\u2010N pyroptosis axis and reduced neutrophil infiltration, attenuating inflammation and preserving hepatocytes. These effects alleviated HIRI and improved liver function, while Fe\n                    <jats:sub>3<\/jats:sub>\n                    O\n                    <jats:sub>4<\/jats:sub>\n                    superparamagnetism enabled magnetic resonance imaging (MRI) for lesion monitoring. Collectively, this nanoplatform synergistically mitigates HIRI via mitochondrial protection and pyroptosis inhibition, coupled with intrinsic MRI monitoring capability.\n                  <\/jats:p>","DOI":"10.1002\/advs.78277","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:30:14Z","timestamp":1792035014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mitochondria\u2010Targeting Iron\u2013Carbon Nanozymes Combat Hepatic Ischemia\u2013Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring"],"prefix":"10.1002","author":[{"given":"Qianying","family":"Du","sequence":"first","affiliation":[{"name":"Department of Radiology Second Affiliated Hospital of Chongqing Medical University  Chongqing P. R. China"},{"name":"Key Laboratory of Intelligent Processing and Applications of Medical Imaging Big Data Chongqing Municipal Health Commission  Chongqing P. R. China"},{"name":"Engineering Research Center for Fundamental and Translational Intelligent Molecular Imaging Chongqing Municipal Education Commission  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Affiliated Hospital of Chongqing Medical University  Chongqing P. R. China"},{"name":"Key Laboratory of Intelligent Processing and Applications of Medical Imaging Big Data Chongqing Municipal Health Commission  Chongqing P. R. China"},{"name":"Engineering Research Center for Fundamental and Translational Intelligent Molecular Imaging Chongqing Municipal Education Commission  Chongqing P. R. 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China"},{"name":"Key Laboratory of Intelligent Processing and Applications of Medical Imaging Big Data Chongqing Municipal Health Commission  Chongqing P. R. China"},{"name":"Engineering Research Center for Fundamental and Translational Intelligent Molecular Imaging Chongqing Municipal Education Commission  Chongqing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-9842","authenticated-orcid":false,"given":"Ying","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Affiliated Hospital of Chongqing Medical University  Chongqing P. R. China"},{"name":"Key Laboratory of Intelligent Processing and Applications of Medical Imaging Big Data Chongqing Municipal Health Commission  Chongqing P. R. China"},{"name":"Engineering Research Center for Fundamental and Translational Intelligent Molecular Imaging Chongqing Municipal Education Commission  Chongqing P. R. 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