{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:44:16Z","timestamp":1792039456373,"version":"4.4.0"},"reference-count":68,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370086"],"award-info":[{"award-number":["82370086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301756"],"award-info":[{"award-number":["82301756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400108"],"award-info":[{"award-number":["82400108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402551"],"award-info":[{"award-number":["82402551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neutrophil extracellular trap (NET) formation, termed NETosis, is a key driver of lung tissue injury in acute lung injury\/acute respiratory distress syndrome (ALI\/ARDS). However, the precise mechanisms that trigger neutrophil NETosis remain incompletely understood. Here, we observed that neutrophils from both ALI mice and ARDS patients exhibited NETosis alongside a pronounced selective metabolic shift, characterized by enhanced oxidative phosphorylation (OXPHOS) and attenuated glycolytic activity. Phosphoproteomic profiling revealed that this shift was driven by aberrant activation of pyruvate dehydrogenase E1 subunit alpha (PDHA1), resulting from its dephosphorylation at Ser293. Inhibiting PDHA1 activity, using either the inhibitor 3\u2010fluoropyruvate (3\u2010FP) or genetic knockdown, effectively reversed this selective metabolic reprogramming and suppressed NETosis. We further constructed neutrophil\u2010targeted 3\u2010FP\u2010loaded albumin nanoparticles (3\u2010FP\u2010BSA NPs). These nanoparticles were specifically taken up by activated neutrophils, markedly inhibited NETosis, and alleviated lipopolysaccharide\u2010induced ALI in mice. Mechanistically, RNA\u2010seq revealed the enrichment of the AMPK in neutrophils during NETosis. AMPK phosphorylated PDHA1 at Ser314, which disrupted the PDHA1\u2010pyruvate dehydrogenase kinase 1 (PDK1) interaction and inhibited PDHA1 phosphorylation at Ser293. Ultimately, PDHA1 hyperactivation\u2010driven selective metabolic reprogramming precipitated mitochondrial stress and mtROS accumulation, thereby initiating NETosis. This study defines a targetable metabolic pathway in neutrophils and advances a specific PDHA1\u2010nanotherapeutic strategy against ALI\/ARDS.<\/jats:p>","DOI":"10.1002\/advs.78307","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:48:01Z","timestamp":1792036081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PDHA1 Hyperactivation\u2010Mediated Glucose Metabolism Reprogramming Fuels Neutrophil NETosis and Promotes Acute Lung Injury"],"prefix":"10.1002","author":[{"given":"Yu\u2010Biao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Geriatric Respiratory and Critical Care Medicine Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"School of Nursing Shandong Xiehe University  Jinan Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5026-5943","authenticated-orcid":false,"given":"Wen\u2010Jing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Xiangya Nursing School Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"},{"name":"Basic and Clinical Research in Major Respiratory Disease Key Laboratory of General University of Hunan Province  Changsha Hunan China"},{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Rui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"},{"name":"Basic and Clinical Research in Major Respiratory Disease Key Laboratory of General University of Hunan Province  Changsha Hunan China"},{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan\u2010Shi\u2010Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"},{"name":"Basic and Clinical Research in Major Respiratory Disease Key Laboratory of General University of Hunan Province  Changsha Hunan China"},{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Xi","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Ling","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"},{"name":"Basic and Clinical Research in Major Respiratory Disease Key Laboratory of General University of Hunan Province  Changsha Hunan China"},{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"},{"name":"Basic and Clinical Research in Major Respiratory Disease Key Laboratory of General University of Hunan Province  Changsha Hunan China"},{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Tong","family":"Yang","sequence":"additional","affiliation":[{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Ying","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"},{"name":"Basic and Clinical Research in Major Respiratory Disease Key Laboratory of General University of Hunan Province  Changsha Hunan China"},{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6517-9013","authenticated-orcid":false,"given":"Jian\u2010Bing","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Emergency Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9839-2342","authenticated-orcid":false,"given":"Shao\u2010Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine The Second Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8505-8724","authenticated-orcid":false,"given":"Cha\u2010Xiang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Geriatric Respiratory and Critical Care Medicine Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"School of Basic Medicine Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-8109","authenticated-orcid":false,"given":"Jia\u2010Xi","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Geriatric Respiratory and Critical Care Medicine Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7348-2376","authenticated-orcid":false,"given":"Yong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Physiology Xiangya School of Basic Medical Sciences Central South University  Changsha Hunan China"},{"name":"Basic and Clinical Research in Major Respiratory Disease Key Laboratory of General University of Hunan Province  Changsha Hunan China"},{"name":"National Experimental Teaching Demonstration Center For Medical Function  Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s00134-025-08251-y","article-title":"The Medical Management of Acute Respiratory Distress Syndrome","volume":"52","author":"Morris I. S.","year":"2026","journal-title":"Intensive Care Medicine"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj\u20102023\u2010076612"},{"issue":"10300","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","article-title":"Acute Respiratory Distress Syndrome","volume":"398","author":"Meyer N. J.","year":"2021","journal-title":"Lancet"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)01485\u20104"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02590\u20102017"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023019940"},{"issue":"1","key":"e_1_2_13_8_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41423-018-0024-0","article-title":"NETosis, Complement, and Coagulation: A Triangular Relationship","volume":"16","author":"Bont C. M.","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3024"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.162"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.99456"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010026\u201008995\u20105"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010cellbio\u2010020520\u2010111016"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.68"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.77304"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.016"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02099"},{"key":"e_1_2_13_18_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217466","article-title":"Metabolic Reprogramming of Neutrophils in the Tumor Microenvironment: Emerging Therapeutic Targets","volume":"612","author":"Huang S.","year":"2025","journal-title":"Cancer Letters"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.11.030"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.011597698"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.563148"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.10.023"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176021"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.08.043"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102013\u201009\u2010526707"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102765"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020\u2010025\u201001410\u20103"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418\u2010025\u201002374\u20105"},{"issue":"15","key":"e_1_2_13_29_1","doi-asserted-by":"crossref","first-page":"8267","DOI":"10.3390\/ijms23158267","article-title":"COX\u20102\/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy Through Sirt1\/PI3K\/AKT\/mTOR","volume":"23","author":"Zhang C. Y.","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423\u2010019\u20100252\u2010y"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967\u2010023\u201004027\u20104"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31169"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.135351"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556\u2010025\u201001651\u20108"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.016"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2008.10.010"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.09.018"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010017\u20100026\u20103"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5b05583"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2014.17"},{"key":"e_1_2_13_41_1","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1633609","article-title":"Development of CRISPR\/Cas9\u2010mediated CD16b(\u2010\/\u2010) and CD32a(\u2010\/\u2010) Promyelocytic Cell Lines to Study FcgammaR Signaling in human Neutrophils","volume":"16","author":"Cruz\u2010Cardenas J. A.","year":"2025","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.11.028"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.43108"},{"issue":"1","key":"e_1_2_13_44_1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s10020-022-00514-4","article-title":"Fn14 exacerbates Acute Lung Injury by Activating the NLRP3 Inflammasome in Mice","volume":"28","author":"Guan X. X.","year":"2022","journal-title":"Molecular Medicine"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2021.54.11.101"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1899667"},{"issue":"1","key":"e_1_2_13_47_1","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s11033-026-11755-5","article-title":"Targeting Neutrophil Extracellular Traps (NETs): A Promising Immunotherapeutic Approach for Pulmonary Diseases","volume":"53","author":"Cai L.","year":"2026","journal-title":"Molecular Biology Reports"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.01.044"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1554570"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081065"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007693\u20106"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.24.14297"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103069200"},{"issue":"1","key":"e_1_2_13_54_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/toxsci\/kfw035","article-title":"Cardiac\u2010Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress","volume":"151","author":"Sun W.","year":"2016","journal-title":"Toxicological Sciences"},{"key":"e_1_2_13_55_1","first-page":"1398","article-title":"PDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence","volume":"9","author":"Zhong W. J.","year":"2026","journal-title":"Research (Wash D C)"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.05.010"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde\u20102017\u20100081"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15071881"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010021\u201000483\u20108"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010025\u201008027\u20108"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2084862"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.108935"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.188971"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2021.112614"},{"issue":"9","key":"e_1_2_13_66_1","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/j.clnu.2024.08.007","article-title":"FNDC4 reduces Hepatocyte Inflammatory Cell Death via AMPKalpha in Metabolic Dysfunction\u2010associated Steatotic Liver Disease","volume":"43","author":"Neira G.","year":"2024","journal-title":"Clinical Nutrition"},{"key":"e_1_2_13_67_1","first-page":"1849","article-title":"Alkaline pH Promotes NADPH Oxidase\u2010Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone","volume":"8","author":"Breda L. C. D.","year":"2017","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004979\u20105"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78307","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78307","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:48:04Z","timestamp":1792036084000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":68,"alternative-id":["10.1002\/advs.78307"],"URL":"https:\/\/doi.org\/10.1002\/advs.78307","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2026-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78307"}}