{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:37:54Z","timestamp":1792730274191,"version":"4.5.0"},"reference-count":285,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U25D9019"],"award-info":[{"award-number":["U25D9019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501180"],"award-info":[{"award-number":["82501180"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226\u20102025\u201000004"],"award-info":[{"award-number":["226\u20102025\u201000004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Traumatic neural injuries, including traumatic brain injury (TBI), spinal cord injury (SCI), and peripheral nerve injury (PNI), impose a substantial global burden. These injuries converge on oxidative stress, neuroinflammation, regulated cell death, demyelination, and extracellular matrix remodeling, while diverging in timing, cellular effectors, and regenerative capacity. Current management still fails to arrest secondary injury or restore functional neural circuitry. Nanomedicine integrates targeted delivery, microenvironmental regulation, and regenerative support, yet existing strategies and reviews remain compartmentalized by injury type or material class. Such fragmentation constrains the integration of shared mechanisms with injury\u2010specific requirements. To address this gap, we develop a cross\u2010injury framework for nanoparticle\u2010based intervention. Separate reanalysis of three single\u2010cell datasets suggests recurrent myeloid involvement and injury\u2010specific within\u2010dataset patterns. We compare lipid\u2010based, polymeric, inorganic, carbon\u2010based, biomimetic, and hybrid platforms in relation to physicochemical properties and biological fate. Six paradigms are organized by pathological need: scaffold construction and microenvironment remodeling, topographical guidance, biomimetic targeting, endogenous stimulus\u2010responsive release, external physical\u2010field activation, and intracellular reprogramming. We trace evolution from passive encapsulation to multi\u2010omics\u2010guided and artificial intelligence (AI)\u2010assisted precision design and examine barriers to manufacturing, biodistribution, safety, protein\u2010corona control, and regulatory evaluation. This framework connects injury mechanisms, functional needs, and material selection to guide translation.<\/jats:p>","DOI":"10.1002\/advs.78308","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:57:53Z","timestamp":1792727873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6377-7648","authenticated-orcid":false,"given":"Mouyuan","family":"Sun","sequence":"first","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangyang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixu","family":"He","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxian","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9151-9962","authenticated-orcid":false,"given":"Xuankai","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luying","family":"Qin","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8363-4453","authenticated-orcid":false,"given":"Lianjie","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1131-7455","authenticated-orcid":false,"given":"Huiming","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-4697","authenticated-orcid":false,"given":"Mengfei","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Stomatology Zhejiang Provincial Clinical Research Center for Oral Diseases Stomatology Hospital Zhejiang University School of Medicine Zhejiang Key Laboratory of Oral Biomedical  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17352"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102023\u2010075049"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbag015"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1965"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001432"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/21925682231189928"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0000000000002767"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202502795"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202509405"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125316"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114180"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202416548"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202503343"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6c01086"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads3398"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c09066"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202412526"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2023.102087"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2024.102193"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010024\u201001754\u20107"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201073036\u2010w"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010024\u201007504\u2010y"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010020\u201000744\u20101"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010025\u201003514\u20103"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2024.106928"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.68457"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2411811122"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31815e6370"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404304"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.5249\/jivr.v9i1.843"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2019.6854"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7096"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2504697122"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20210040"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.80881"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.12.061"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2024.e00515"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1358646"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.861428"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.008"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5294.1921"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR\u2010D\u201023\u201001863"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.91.5.0737"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010021\u201001236\u20100"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010026\u201003724\u20103"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.11.052"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974\u2010022\u201002602\u2010y"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22\u201023\u201010368.2002"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.021"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270874"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17623"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201050564\u2010x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202516269"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001585\u2010y"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.3c00769"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.118278"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.08.008"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.02.007"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011593\u2010z"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.08.031"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c02610"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202102256"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100546"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2024.114245"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121365"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/polymscitech.5c00010"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpolymj.2022.111417"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010025\u201002410\u2010x"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.01.035"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj1083"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.07.057"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101670"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010025\u201031750\u20103"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121244"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd6889"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2022.100214"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.162247"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122811"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.011"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2025.214563"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2025.121483"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/cbe.5c00048"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.6b02086"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compositesb.2022.110129"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/smmd.70025"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c03215"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010026\u201004127\u20105"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2023.07.132"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.180177"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123682"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400586"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989\u2010024\u201000565\u2010x"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202507451"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.75272"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157285"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.5c00545"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002753\u20105"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571\u2010025\u201001612\u20107"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/plphys\/kiag141"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.01.002"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401724"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202416020"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.11.007"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054\u2010025\u201005477\u20106"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1080\/14789450.2018.1464914"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjprs.2025.05.001"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2025.11.005"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287\u2010024\u201003868\u20100"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202416085"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/polymscitech.6c00004"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c09794"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c21336"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003909\u20107"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmst.2026.05.056"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18918"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsanm.4c06034"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.139285"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2025.08.042"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5tb01557j"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.5c03705"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43939\u2010025\u201000489\u2010z"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202514076"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1307152110"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3tb00322a"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1039\/d4nr02408g"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.152"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2026.152050"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033044\u2010y"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.70947"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010021\u201001097\u20108"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202514389"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c08608"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.4c01179"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5cs01504a"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435390.2021.1905899"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565\u2010023\u201001551\u20108"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.03.009"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202406802"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c19138"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032568"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm\u20102017\u20100022"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2bm01846b"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248\u2010021\u201000626\u20105"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c21926"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.34835"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303867"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.01.065"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c16391"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121310"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.018"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c08863"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.05.036"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000583\u20108"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c08237"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20240229"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110433"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010026\u201005034\u20100"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101335"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42242\u2010024\u201000318\u2010x"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003098\u20103"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c14902"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1631\/bdm.2500026"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010026\u201004553\u20105"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.161831"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673\u20105374.335160"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.179095"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202524264"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.157681"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.71430"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001116"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.4103\/ATN.ATN\u2010D\u201024\u201000010"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.103433"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbae075"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.153809"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010019\u20100463\u20105"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.176383"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010025\u201003251\u2010y"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202205787"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2026.114683"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2025.138290"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.09.032"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.2147\/ijn.S547401"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2026.103189"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010024\u201002302\u20100"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202509444"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.03.003"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.70012"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202513825"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2024.05.015"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1080\/17590914.2026.2678168"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.77351"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101411"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202209658"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.149521"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2025.102833"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41563\u2010026\u201002625\u20103"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.07.050"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ads4938"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202307896"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765\u2010025\u201000516\u2010x"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202523049"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00794"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2026.103116"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c19897"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304261"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123708"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c10725"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202522093"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.5c15144"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202305374"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.158386"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celbio.2025.100130"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020276"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2015.1034280"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11980"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2026.173441"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.07.008"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122995"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2025.02.034"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c05818"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2024.06.021"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010022\u201033184\u20101"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100618\u20106"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010026\u201008596\u20102"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.100996"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2024.102413"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2022.103236"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2025.114426"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2010.12.030"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm\u20102021\u20100413"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13070569"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000001932"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1227\/neu.0000000000003180"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2023.2152001"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122368"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10010132"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20103816\u20102_17"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114267"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme\u20102023\u20100102"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666210406115529"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1080\/17435889.2025.2533107"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c24\u201000089"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.4103\/ATN.ATN\u2010D\u201024\u201000026"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951\u2010023\u201002236\u2010z"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00390"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2024.01.002"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41393\u2010021\u201000698\u20102"},{"key":"e_1_2_12_249_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.4122"},{"key":"e_1_2_12_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.05.011"},{"key":"e_1_2_12_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201055914\u2010x"},{"key":"e_1_2_12_252_1","doi-asserted-by":"publisher","DOI":"10.1002\/ams2.622"},{"key":"e_1_2_12_253_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000955\u2010x"},{"key":"e_1_2_12_254_1","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3390\/cells9040977","article-title":"Circulating Brain Injury Exosomal Proteins Following Moderate\u2010to\u2010Severe Traumatic Brain Injury: Temporal Profile, Outcome Prediction and Therapy Implications","volume":"9","author":"Mondello S.","year":"2020","journal-title":"Cells"},{"key":"e_1_2_12_255_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1288740"},{"key":"e_1_2_12_256_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2026.15678"},{"key":"e_1_2_12_257_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202006644"},{"key":"e_1_2_12_258_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010025\u201000481\u2010w"},{"key":"e_1_2_12_259_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000009985"},{"key":"e_1_2_12_260_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010026\u201071412\u20100"},{"key":"e_1_2_12_261_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44222\u2010024\u201000264\u20104"},{"key":"e_1_2_12_262_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c01993"},{"key":"e_1_2_12_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2025.05.011"},{"key":"e_1_2_12_264_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2026.115781"},{"key":"e_1_2_12_265_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01400674"},{"key":"e_1_2_12_266_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc6887"},{"key":"e_1_2_12_267_1","doi-asserted-by":"publisher","DOI":"10.4103\/2277\u20109175.100176"},{"key":"e_1_2_12_268_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1411090"},{"key":"e_1_2_12_269_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.6490"},{"key":"e_1_2_12_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(15)00386\u20104"},{"key":"e_1_2_12_271_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.13256"},{"issue":"9475","key":"e_1_2_12_272_1","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/S0140-6736(05)66552-X","article-title":"Final Results of MRC CRASH, a Randomised Placebo\u2010controlled Trial of Intravenous Corticosteroid in Adults with Head Injury\u2010outcomes at 6 Months","volume":"365","author":"Edwards P.","year":"2005","journal-title":"Lancet"},{"key":"e_1_2_12_273_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199106273242601"},{"key":"e_1_2_12_274_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2023.0163"},{"key":"e_1_2_12_275_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa466"},{"key":"e_1_2_12_276_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.6.SPINE18209"},{"key":"e_1_2_12_277_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.11.SPINE17769"},{"key":"e_1_2_12_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2018.03.011"},{"key":"e_1_2_12_279_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2023.05.020"},{"key":"e_1_2_12_280_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534\u2010200010000\u201000013"},{"key":"e_1_2_12_281_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.04.087"},{"key":"e_1_2_12_282_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2020.07.016"},{"key":"e_1_2_12_283_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13122954"},{"issue":"10","key":"e_1_2_12_284_1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00701-007-1269-z","article-title":"Radial Nerve Repair Using an Autologous Denatured Muscle Graft: Comparison with Outcomes of Nerve Graft Repair","volume":"149","author":"Roganovic Z.","year":"2007","journal-title":"Acta Neurochirurgica (Wien)"},{"key":"e_1_2_12_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anplas.2009.03.003"},{"key":"e_1_2_12_286_1","doi-asserted-by":"publisher","DOI":"10.31083\/FBL38904"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:57:56Z","timestamp":1792727876000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":285,"alternative-id":["10.1002\/advs.78308"],"URL":"https:\/\/doi.org\/10.1002\/advs.78308","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"2026-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78308"}}