{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:42:02Z","timestamp":1792341722351,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370506"],"award-info":[{"award-number":["82370506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Blood\u2010brain barrier (BBB) preserves brain homeostasis yet restricts therapeutics; in bacterial meningitis, antibiotics\u2019 limited penetration impairs delivery to the parenchyma and cerebrospinal fluid, constraining efficacy and motivating strategies to overcome the barrier. To address this, we developed a chiral virus\u2010mimicking mesoporous silica nanostructure (CVSN) functionalized with L\u2010alanine for antibiotic delivery. It offers several distinct advantages: (1) nanoscale dimensions facilitating BBB transport; (2) virus\u2010like morphology enhancing vascular accumulation and penetration, providing a foundation for passive targeting; (3) chiral surface modification conferring active recognition capacity for more efficient biological targeting; and (4) a mesoporous architecture that ensures high drug\u2010loading efficiency and controlled release of drugs. Experimentally, it achieves efficient BBB penetration into the brain parenchyma and shows targeted delivery into microglia and astrocytes. Simulating the loading of cargoes by viruses, it ultimately improves the bioavailability and brain parenchyma and cerebrospinal fluid contents of various antibiotics with distinct physicochemical properties, antibacterial spectrum, and BBB penetration capacity, including cefoperazone, norfloxacin, levofloxacin and imipenem. It helps to treat meningitis induced by both Gram\u2010negative bacteria (e.g.,\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ) and Gram\u2010positive bacteria (e.g.,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ) and provides a promising avenue to overcome the limitations imposed by the BBB for CNS infections antibiotic therapy in clinic.\n                  <\/jats:p>","DOI":"10.1002\/advs.78317","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:08:16Z","timestamp":1792339696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Chiral Virus\u2010Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy"],"prefix":"10.1002","author":[{"given":"Qianqian","family":"Xu","sequence":"first","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"},{"name":"Department of Neurosurgery the Fourth Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-201X","authenticated-orcid":false,"given":"Xuting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huinan","family":"Tong","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6258-6711","authenticated-orcid":false,"given":"Ziyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Du","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2876-1525","authenticated-orcid":false,"given":"Heran","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6128-5757","authenticated-orcid":false,"given":"Guojun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery the Fourth Affiliated Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12964-023-01383-y","article-title":"TGF\u03b21\u2010Induced Hedgehog Signaling Suppresses the Immune Response of Brain Microvascular Endothelial Cells Elicited by Meningitic Escherichia Coli","volume":"22","author":"Sun J.","year":"2024","journal-title":"Cell Communication and Signaling"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2025.2542246","article-title":"Three\u2010Dimensional Mapping of Tick\u2010borne Encephalitis Virus Distribution in the Mouse Brain Using a Newly Engineered TurboGFP Reporter Virus","volume":"14","author":"Berankova M.","year":"2025","journal-title":"Emerging Microbes & Infections"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1474-4422(23)00195-3","article-title":"Global, Regional, and National Burden of Meningitis and its Aetiologies, 1990\u20132019: A Systematic Analysis for the Global Burden of Disease Study 2019","volume":"22","author":"Collaborators G. 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