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Plant exosome\u2010like nanovesicles can transport proteins, lipids, and molecular compounds between neural cells and the periphery, thereby modulating target cells. This study examined the therapeutic potential of\n                    <jats:italic>Chrysanthemum morifolium<\/jats:italic>\n                    \u2013derived exosome\u2010like nanovesicles (CRELNVs) in an animal model of lipopolysaccharide\u2010induced SAE, revealing their ability to effectively cross the blood\u2013brain barrier, be internalized by microglia, and alleviate nerve injury and memory impairment by reducing lactate levels in microglia at the hippocampus. CRELNVs decreased lactylation levels in microglia, thus promoting the conversion of microglial cells from the detrimental M1 metabolic phenotype to the protective M2 one. Mechanistically, our finding suggest CRELNVs reduced proinflammatory cytokine release is associated with the inhibition of NF\u2010\u03baB activation. Thus, CRELNVs were concluded to exert their protective effects by modulating the H3K18la\/NF\u2010\u03baB axis and regulate microglia\u2010mediated neuroinflammation by responding to the hippocampal neuritis\u2013induced injury in SAE.\n                  <\/jats:p>","DOI":"10.1002\/advs.78330","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:09:41Z","timestamp":1792037381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>Chrysanthemum Morifolium\u2013<\/i>\n                    Derived Nanovesicles Reduce Lactate\u2010Associated Histone Lactylation and Modulate Microglia\u2010Mediated Neuroinflammation in Sepsis\u2010Associated Encephalopathy"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-0845","authenticated-orcid":false,"given":"Kaiqiang","family":"Li","sequence":"first","affiliation":[{"name":"Center for Laboratory Medicine Allergy 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