{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:41:49Z","timestamp":1792341709336,"version":"4.4.0"},"reference-count":62,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32595480"],"award-info":[{"award-number":["32595480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32500636"],"award-info":[{"award-number":["32500636"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32500638"],"award-info":[{"award-number":["32500638"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31970820"],"award-info":[{"award-number":["31970820"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["22120250374"],"award-info":[{"award-number":["22120250374"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Adult pancreatic acinar cells undergo ordered metaplastic conversion during injury and tumor initiation. Whether individual cells retain redifferentiation capacity after metaplastic expansion, and what signals each transition requires, remains unknown. Here, using organoids derived from single acinar cells, we show that expanded acinar\u2010lineage organoids can reacquire acinar features under stage\u2010specific culture conditions. We defined conditions that preserve acinar identity ex vivo and showed that epidermal growth factor (EGF)\/EGF receptor (EGFR) signaling initiates conversion from this maintained state. The expansion trajectory recapitulates injury\u2010 and oncogene\u2010associated acinar\u2010to\u2010ductal metaplasia (ADM) programs in vivo. After expansion, the conditions that preserved acinar identity could not restore it; a staged regimen containing transient insulin\u2010like growth factor 1 receptor (IGF1R) inhibition and dexamethasone promoted redifferentiation. The Kras\n                    <jats:sup>G12D<\/jats:sup>\n                    ;Trp53\n                    <jats:sup>R172H<\/jats:sup>\n                    ;Pdx1\u2010Cre (\n                    <jats:italic>KPC<\/jats:italic>\n                    ) genotype reduced EGFR dependence during initiation but destabilized post\u2010expansion redifferentiation;\n                    <jats:italic>Kras<\/jats:italic>\n                    \u2010pathway inhibition increased endpoint acinar\u2010marker expression. These findings demonstrate that acinar plasticity is organized by stage\u2010specific signals, and that the\n                    <jats:italic>KPC<\/jats:italic>\n                    genotype disrupts this control at specific transition points.\n                  <\/jats:p>","DOI":"10.1002\/advs.78350","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:05:47Z","timestamp":1792339547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acinar\u2010Derived Organoids Reveal Stage\u2010Specific Control of Acinar Plasticity"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1332-3064","authenticated-orcid":false,"given":"Yongfei","family":"Hou","sequence":"first","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunying","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifan","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"He","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"},{"name":"Medical Innovation Center Shanghai East Hospital School of Medicine Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Fu","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5834-1604","authenticated-orcid":false,"given":"Tianping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Zhabei Central Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8624-8928","authenticated-orcid":false,"given":"Xiaolei","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute for Regenerative Medicine State Key Laboratory of Cardiovascular Diseases Shanghai East Hospital Frontier Science Center for Stem Cell Research School of Life Sciences and Technology Tongji University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.gastro.2010.04.003","article-title":"Replacement of Rbpj with Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells","volume":"139","author":"Masui T.","year":"2010","journal-title":"Gastroenterology"},{"issue":"16","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1101\/gad.16860911","article-title":"LRH\u20101 and PTF1\u2010L Coregulate an Exocrine Pancreas\u2010Specific Transcriptional Network for Digestive Function","volume":"25","author":"Holmstrom S. R.","year":"2011","journal-title":"Genes & Development"},{"issue":"23","key":"e_1_2_9_4_1","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1128\/MCB.00370-16","article-title":"MIST1 and PTF1 Collaborate in Feed\u2010Forward Regulatory Loops That Maintain the Pancreatic Acinar Phenotype in Adult Mice","volume":"36","author":"Jiang M.","year":"2016","journal-title":"Molecular and Cellular Biology"},{"issue":"24","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"3033","DOI":"10.1128\/MCB.00358-16","article-title":"Transcriptional Maintenance of Pancreatic Acinar Identity, Differentiation, and Homeostasis by PTF1A","volume":"36","author":"Hoang C. Q.","year":"2016","journal-title":"Molecular and Cellular Biology"},{"issue":"4","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1136\/gutjnl-2012-304287","article-title":"Nr5a2 maintains Acinar Cell Differentiation and Constrains Oncogenic Kras\u2010Mediated Pancreatic Neoplastic Initiation","volume":"63","author":"Figura G.","year":"2014","journal-title":"Gut"},{"key":"e_1_2_9_7_1","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.07125","article-title":"The Acinar Differentiation Determinant PTF1A Inhibits Initiation of Pancreatic Ductal Adenocarcinoma","volume":"4","author":"Krah N. M.","year":"2015","journal-title":"eLife"},{"issue":"3","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ccr.2007.01.012","article-title":"Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K\u2010Ras Oncogenes in Adult Mice","volume":"11","author":"Guerra C.","year":"2007","journal-title":"Cancer Cell"},{"issue":"48","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"18913","DOI":"10.1073\/pnas.0810097105","article-title":"Spontaneous Induction of Murine Pancreatic Intraepithelial Neoplasia (mPanIN) by Acinar Cell Targeting of Oncogenic Kras in Adult Mice","volume":"105","author":"Habbe N.","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.ccr.2012.10.025","article-title":"Identification of Sox9\u2010Dependent Acinar\u2010to\u2010Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma","volume":"22","author":"Kopp J. L.","year":"2012","journal-title":"Cancer Cell"},{"issue":"2","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1172\/JCI40045","article-title":"\u03b2\u2010Catenin Blocks Kras\u2010Dependent Reprogramming of Acini into Pancreatic Cancer Precursor Lesions in Mice","volume":"120","author":"Morris J. P.","year":"2010","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2353\/ajpath.2007.061176","article-title":"Acinar Cells Contribute to the Molecular Heterogeneity of Pancreatic Intraepithelial Neoplasia","volume":"171","author":"Zhu L.","year":"2007","journal-title":"The American Journal of Pathology"},{"issue":"4","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1053\/j.gastro.2024.04.031","article-title":"Resolution of Acinar Dedifferentiation Regulates Tissue Remodeling in Pancreatic Injury and Cancer Initiation","volume":"167","author":"Baldan J.","year":"2024","journal-title":"Gastroenterology"},{"issue":"6","key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1053\/j.gastro.2007.09.009","article-title":"In Vivo Lineage Tracing Defines the Role of Acinar\u2010to\u2010Ductal Transdifferentiation in Inflammatory Ductal Metaplasia","volume":"133","author":"Strobel O.","year":"2007","journal-title":"Gastroenterology"},{"issue":"6","key":"e_1_2_9_15_1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.devcel.2019.07.012","article-title":"Prevention and Reversion of Pancreatic Tumorigenesis through a Differentiation\u2010Based Mechanism","volume":"50","author":"Krah N. M.","year":"2019","journal-title":"Developmental Cell"},{"issue":"5","key":"e_1_2_9_16_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcmgh.2025.101717","article-title":"Novel Acinar Metaplastic States Uncovered in Exocrine Pancreas Disease","volume":"20","author":"Aney K. J.","year":"2025","journal-title":"Cellular and Molecular Gastroenterology and Hepatology"},{"issue":"6","key":"e_1_2_9_17_1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1053\/j.gastro.2024.01.043","article-title":"Novel Approach for Pancreas Transcriptomics Reveals the Cellular Landscape in Homeostasis and Acute Pancreatitis","volume":"166","author":"Aney K. J.","year":"2024","journal-title":"Gastroenterology"},{"issue":"2","key":"e_1_2_9_18_1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1053\/j.gastro.2021.10.027","article-title":"Single\u2010Cell Transcriptomics Reveals a Conserved Metaplasia Program in Pancreatic Injury","volume":"162","author":"Ma Z.","year":"2022","journal-title":"Gastroenterology"},{"issue":"1","key":"e_1_2_9_19_1","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1038\/s41467-020-18207-z","article-title":"Single\u2010Cell Transcriptomes of Pancreatic Preinvasive Lesions and Cancer Reveal Acinar Metaplastic Cells' heterogeneity","volume":"11","author":"Schlesinger Y.","year":"2020","journal-title":"Nature Communications"},{"issue":"3","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.devcel.2016.10.002","article-title":"Single\u2010Cell Analysis Uncovers Clonal Acinar Cell Heterogeneity in the Adult Pancreas","volume":"39","author":"Wollny D.","year":"2016","journal-title":"Developmental Cell"},{"issue":"3","key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ccr.2012.07.024","article-title":"EGF Receptor Is Required for KRAS\u2010Induced Pancreatic Tumorigenesis","volume":"22","author":"Ardito C. M.","year":"2012","journal-title":"Cancer Cell"},{"issue":"2","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1172\/JCI59227","article-title":"Oncogenic Kras Is Required for both the Initiation and Maintenance of Pancreatic Cancer in Mice","volume":"122","author":"Collins M. A.","year":"2012","journal-title":"Journal of Clinical Investigation"},{"issue":"3","key":"e_1_2_9_23_1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ccr.2012.08.001","article-title":"EGF Receptor Signaling Is Essential for k\u2010ras Oncogene\u2010Driven Pancreatic Ductal Adenocarcinoma","volume":"22","author":"Navas C.","year":"2012","journal-title":"Cancer Cell"},{"issue":"1","key":"e_1_2_9_24_1","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1038\/s41598-019-40481-1","article-title":"Adult human Pancreatic Acinar Cells Dedifferentiate into an Embryonic Progenitor\u2010Like state in 3D Suspension Culture","volume":"9","author":"Baldan J.","year":"2019","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_9_25_1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41420-022-01165-4","article-title":"Pharmacological Inhibition and Reversal of Pancreatic Acinar Ductal Metaplasia","volume":"8","author":"Silva L.","year":"2022","journal-title":"Cell Death Discovery"},{"issue":"2","key":"e_1_2_9_26_1","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1053\/j.gastro.2011.04.050","article-title":"Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of human Pancreas","volume":"141","author":"Houbracken I.","year":"2011","journal-title":"Gastroenterology"},{"issue":"7","key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/gut.2010.225920","article-title":"Adult Pancreatic Acinar Cells Dedifferentiate to an Embryonic Progenitor Phenotype with Concomitant Activation of a Senescence Programme That Is Present in Chronic Pancreatitis","volume":"60","author":"Pinho A. V.","year":"2011","journal-title":"Gut"},{"issue":"144","key":"e_1_2_9_28_1","article-title":"Mimicking and Manipulating Pancreatic Acinar\u2010to\u2010Ductal Metaplasia in 3\u2010Dimensional Cell Culture","author":"Martinez A. K. F.","year":"2019","journal-title":"Journal of Visualized Experiments: JoVE"},{"issue":"1","key":"e_1_2_9_29_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2014.12.021","article-title":"Organoid Models of human and Mouse Ductal Pancreatic Cancer","volume":"160","author":"Boj S. F.","year":"2015","journal-title":"Cell"},{"issue":"1","key":"e_1_2_9_30_1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12861-020-0209-5","article-title":"Long\u2010Term Expansion, Genomic Stability and in Vivo Safety of Adult human Pancreas Organoids","volume":"20","author":"Georgakopoulos N.","year":"2020","journal-title":"BMC Developmental Biology"},{"issue":"20","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1038\/emboj.2013.204","article-title":"Unlimited In Vitro Expansion of Adult bi\u2010Potent Pancreas Progenitors through the Lgr5\/R\u2010Spondin Axis","volume":"32","author":"Huch M.","year":"2013","journal-title":"The EMBO Journal"},{"issue":"3","key":"e_1_2_9_32_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.stemcr.2018.02.005","article-title":"Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential","volume":"10","author":"Loomans C. J. M.","year":"2018","journal-title":"Stem Cell Reports"},{"issue":"7","key":"e_1_2_9_33_1","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3724\/abbs.2024218","article-title":"Small Molecules Enhance the High\u2010Efficiency Generation of Pancreatic Ductal Organoids","volume":"57","author":"Liao Y.","year":"2025","journal-title":"Acta Biochimica et Biophysica Sinica"},{"issue":"3","key":"e_1_2_9_34_1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/gutjnl-2016-312423","article-title":"Human Pluripotent Stem Cell\u2010Derived Acinar\/Ductal Organoids Generate Human Pancreas Upon Orthotopic Transplantation and Allow Disease Modelling","volume":"66","author":"Hohwieler M.","year":"2017","journal-title":"Gut"},{"issue":"6","key":"e_1_2_9_35_1","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.stem.2021.03.022","article-title":"Commitment and Oncogene\u2010Induced Plasticity of human Stem Cell\u2010Derived Pancreatic Acinar and Ductal Organoids","volume":"28","author":"Huang L.","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"2","key":"e_1_2_9_36_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.stem.2025.12.023","article-title":"High\u2010Content Screening of Organoids Reveals the Mechanisms of human Pancreas Acinar Specification","volume":"33","author":"Keshara R.","year":"2026","journal-title":"Cell Stem Cell"},{"issue":"1","key":"e_1_2_9_37_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1038\/s41467-024-45097-2","article-title":"Reconstitution of human PDAC Using Primary Cells Reveals Oncogenic Transcriptomic Features at Tumor Onset","volume":"15","author":"Xu Y.","year":"2024","journal-title":"Nature Communications"},{"issue":"1","key":"e_1_2_9_38_1","doi-asserted-by":"crossref","DOI":"10.1172\/JCI194395","article-title":"NF2 loss Malignantly Transforms human Pancreatic Acinar Cells and Enhances Cell Fitness under Environmental Stress","volume":"136","author":"Xu Y.","year":"2026","journal-title":"Journal of Clinical Investigation"},{"issue":"1","key":"e_1_2_9_39_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A Robust and High\u2010Throughput Cre Reporting and Characterization System for the Whole Mouse Brain","volume":"13","author":"Madisen L.","year":"2010","journal-title":"Nature Neuroscience"},{"issue":"1","key":"e_1_2_9_40_1","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btac746","article-title":"scFates: A Scalable Python Package for Advanced Pseudotime and Bifurcation Analysis from Single\u2010Cell Data","volume":"39","author":"Faure L.","year":"2023","journal-title":"Bioinformatics"},{"issue":"5","key":"e_1_2_9_41_1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00006676-199109000-00002","article-title":"Growth and Differentiation of Pancreatic Acinar Cells","volume":"6","author":"Guthrie J.","year":"1991","journal-title":"Pancreas"},{"issue":"5","key":"e_1_2_9_42_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","article-title":"Trp53R172H and KrasG12D Cooperate to Promote Chromosomal Instability and Widely Metastatic Pancreatic Ductal Adenocarcinoma in Mice","volume":"7","author":"Hingorani S. R.","year":"2005","journal-title":"Cancer Cell"},{"issue":"4","key":"e_1_2_9_43_1","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1021\/acs.jmedchem.1c01688","article-title":"Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS G12D Inhibitor","volume":"65","author":"Wang X.","year":"2022","journal-title":"Journal of Medicinal Chemistry"},{"issue":"7968","key":"e_1_2_9_44_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41586-023-06123-3","article-title":"Pan\u2010KRAS Inhibitor Disables Oncogenic Signalling and Tumour Growth","volume":"619","author":"Kim D.","year":"2023","journal-title":"Nature"},{"issue":"6561","key":"e_1_2_9_45_1","doi-asserted-by":"crossref","DOI":"10.1126\/science.abj0486","article-title":"Epithelial Memory of Inflammation Limits Tissue Damage While Promoting Pancreatic Tumorigenesis","volume":"373","author":"Del Poggetto E.","year":"2021","journal-title":"Science"},{"issue":"24","key":"e_1_2_9_46_1","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/j.devcel.2023.11.008","article-title":"A Reversible Epigenetic Memory of Inflammatory Injury Controls Lineage Plasticity and Tumor Initiation in the Mouse Pancreas","volume":"58","author":"Falvo D. J.","year":"2023","journal-title":"Developmental Cell"},{"issue":"1","key":"e_1_2_9_47_1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-physiol-061121-035954","article-title":"Paligenosis: Cellular Remodeling during Tissue Repair","volume":"84","author":"Brown J. W.","year":"2022","journal-title":"Annual Review of Physiology"},{"issue":"7","key":"e_1_2_9_48_1","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798311","article-title":"Regenerative Proliferation of Differentiated cells by mTORC1\u2010Dependent Paligenosis","volume":"37","author":"Willet S. G.","year":"2018","journal-title":"The EMBO Journal"},{"issue":"78","key":"e_1_2_9_49_1","article-title":"Isolation and Culture of Mouse Primary Pancreatic Acinar Cells","author":"Gout J.","year":"2013","journal-title":"Journal of Visualized Experiments"},{"issue":"7","key":"e_1_2_9_50_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 Years of Image Analysis","volume":"9","author":"Schneider C. A.","year":"2012","journal-title":"Nature Methods"},{"issue":"4","key":"e_1_2_9_51_1","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real\u2010Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak K. J.","year":"2001","journal-title":"Methods"},{"issue":"13","key":"e_1_2_9_52_1","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1016\/j.cell.2021.04.048","article-title":"Integrated Analysis of Multimodal Single\u2010Cell Data","volume":"184","author":"Hao Y.","year":"2021","journal-title":"Cell"},{"issue":"7","key":"e_1_2_9_53_1","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive Integration of Single\u2010Cell Data","volume":"177","author":"Stuart T.","year":"2019","journal-title":"Cell"},{"key":"e_1_2_9_54_1","doi-asserted-by":"crossref","first-page":"979","DOI":"10.12688\/f1000research.73600.1","article-title":"Doublet Identification in Single\u2010Cell Sequencing Data Using scDblFinder","volume":"10","author":"Germain P.\u2010L.","year":"2021","journal-title":"F1000Research"},{"issue":"3","key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/bioinformatics\/btz625","article-title":"BBKNN: Fast Batch Alignment of Single Cell Transcriptomes","volume":"36","author":"Polanski K.","year":"2020","journal-title":"Bioinformatics"},{"issue":"1","key":"e_1_2_9_56_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: Large\u2010Scale Single\u2010Cell Gene Expression Data Analysis","volume":"19","author":"Wolf F. A.","year":"2018","journal-title":"Genome Biology"},{"key":"e_1_2_9_57_1","doi-asserted-by":"crossref","unstructured":"L.McInnes J.Healy andJ.Melville \u201cUMAP: Uniform Manifold Approximation and Projection for Dimension Reduction \u201dpreprint arXiv September 18 2018 https:\/\/doi.org\/10.48550\/arXiv.1802.03426.","DOI":"10.21105\/joss.00861"},{"issue":"1","key":"e_1_2_9_58_1","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1038\/s41598-019-41695-z","article-title":"From Louvain to Leiden: Guaranteeing Well\u2010Connected Communities","volume":"9","author":"Traag V. A.","year":"2019","journal-title":"Scientific Reports"},{"issue":"11","key":"e_1_2_9_59_1","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1038\/s41592-025-02857-2","article-title":"Improved Reconstruction of Single\u2010Cell Developmental Potential with CytoTRACE 2","volume":"22","author":"Kang M.","year":"2025","journal-title":"Nature Methods"},{"issue":"12","key":"e_1_2_9_60_1","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1038\/s41592-018-0229-2","article-title":"Deep Generative Modeling for Single\u2010Cell Transcriptomics","volume":"15","author":"Lopez R.","year":"2018","journal-title":"Nature Methods"},{"issue":"11","key":"e_1_2_9_61_1","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: Single\u2010Cell Regulatory Network Inference and Clustering","volume":"14","author":"Aibar S.","year":"2017","journal-title":"Nature Methods"},{"issue":"7","key":"e_1_2_9_62_1","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-020-0336-2","article-title":"A Scalable SCENIC Workflow for Single\u2010Cell Gene Regulatory Network Analysis","volume":"15","author":"Van de Sande B.","year":"2020","journal-title":"Nature Protocols"},{"issue":"12","key":"e_1_2_9_63_1","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1093\/bioinformatics\/bty916","article-title":"GRNBoost2 and Arboreto: Efficient and Scalable Inference of Gene Regulatory Networks","volume":"35","author":"Moerman T.","year":"2019","journal-title":"Bioinformatics"}],"container-title":["Advanced Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78350","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/advs.78350","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/advs.78350","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:05:55Z","timestamp":1792339555000},"score":1,"resource":{"primary":{"URL":"https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.78350"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,18]]},"references-count":62,"alternative-id":["10.1002\/advs.78350"],"URL":"https:\/\/doi.org\/10.1002\/advs.78350","archive":["Portico"],"relation":{},"ISSN":["2198-3844","2198-3844"],"issn-type":[{"value":"2198-3844","type":"print"},{"value":"2198-3844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,18]]},"assertion":[{"value":"2026-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e78350"}}