{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:43:55Z","timestamp":1792338235488,"version":"4.4.0"},"reference-count":88,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Strain release has long inspired the discovery of unique reactivity, enabling diverse synthetically valuable transformations. Bicyclo[1.1.0]butanes (BCBs), due to their high ring strain, have emerged as versatile building blocks for constructing complex bicyclic architectures. Herein, we report a Lewis acid\u2010catalyzed formal (3 + 3) annulation of BCBs with indolyl alcohols, providing rapid access to indole\u2010fused aza\u2010bicyclo[3.1.1]heptanes. The reaction proceeds under mild conditions, tolerates a broad range of functional groups, and delivers rigid, sp\n                    <jats:sup>3<\/jats:sup>\n                    \u2010rich scaffolds efficiently. Mechanistic studies, including control experiments and computational analysis, indicate a stepwise pathway in which Lewis acid activation of indolyl alcohols generates reactive intermediates, while strain\u2010release of BCBs drives C\u2013C bond formation, followed by C\u2013N bond formation via ring expansion to furnish the fused Aza\u2010bicyclic products.\n                  <\/jats:p>","DOI":"10.1002\/advs.78354","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:06:28Z","timestamp":1792335988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lewis Acid\u2010Catalyzed Strain\u2010Enabled (3+3) Annulation of Bicyclo[1.1.0]Butanes With Indolylalcohols: Synthesis of Indole\u2010Fused Aza\u2010Bicyclo[3.1.1]Heptanes"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2651-2774","authenticated-orcid":false,"given":"Mainak","family":"Dey","sequence":"first","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2281-5120","authenticated-orcid":false,"given":"Tuhin Subhra Das","family":"Mahapatra","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5778-3929","authenticated-orcid":false,"given":"Pragya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8236-3638","authenticated-orcid":false,"given":"Manoj V.","family":"Mane","sequence":"additional","affiliation":[{"name":"Centre For Nano and Material Sciences Jain (Deemed\u2010to\u2010be University)  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5968-5305","authenticated-orcid":false,"given":"Chinmoy Kumar","family":"Hazra","sequence":"additional","affiliation":[{"name":"Department of Chemistry Indian Institute of Technology  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm101356p"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2010.11.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00370K"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901241e"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2md20347b"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1SC00161B"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010023\u201001159\u20104"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adh9737"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202512018"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010022\u201000979\u20100"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41557\u2010021\u201000786\u2010z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c04180"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010020\u20102060\u2010z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201914875"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010025\u201008745\u20101"},{"key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41586-022-05290-z","article-title":"Synthesis 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