{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T05:43:52Z","timestamp":1792561432478,"version":"4.5.0"},"reference-count":98,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372394"],"award-info":[{"award-number":["82372394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572741"],"award-info":[{"award-number":["82572741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Following central nervous system (CNS) injury, reactive astrocytes proliferate and encapsulate the lesion to facilitate repair. However, the specific metabolic characteristics remain unknown. Here, through integrated single\u2010cell and spatial transcriptomics, we uncovered a subset of astrocytes that undergo enhanced lipid and ketone metabolic reprogramming following spinal cord injury (SCI). The ketone body \u03b2\u2010hydroxybutyrate (\u03b2\u2010OHB) inhibited autophagic degradation of carnitine\u2010palmitoyltransferase\u20101A (CPT1A) via P300\u2010mediated lysine \u03b2\u2010hydroxybutyrylation (Kbhb). Astrocyte\u2010specific deletion of\n                    <jats:italic>Cpt1a<\/jats:italic>\n                    led to impaired wound healing, reduced axonal sparing and worsened locomotor recovery after SCI, effects rescued by exogenous \u03b2\u2010OHB. Mechanistically, ketogenesis promotes wound repair and lipid metabolic reprogramming, forming a positive feedback loop via H3K9bhb\u2010dependent epigenetic remodeling in astrocytes after SCI. Furthermore, ketogenic diet (KD) promoted tissue repair across multiple CNS injury models. Clinically, elevated \u03b2\u2010OHB levels were associated with better tissue preservation and functional recovery in SCI patients. Collectively, our findings underscore the critical role of astrocytic lipid metabolic and epigenetic reprogramming after CNS injury and identify KD as a promising therapeutic strategy.\n                  <\/jats:p>","DOI":"10.1002\/advs.78393","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T05:22:51Z","timestamp":1792560171000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9919-4122","authenticated-orcid":false,"given":"Dishui","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu 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Surgery) The First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Fourth Medical Centre of Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2847-952X","authenticated-orcid":false,"given":"Jianquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Second Affiliated Hospital of Naval Medical University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5180-1559","authenticated-orcid":false,"given":"Weihua","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu 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