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Here, we report a bioelectronic hybrid heart that integrates engineered cardiac tissue with embedded electrophysiological sensing and stimulation capabilities. A decellularized cardiac scaffold was cellularized by injection of induced pluripotent stem cell\u2010derived cardiomyocytes and assembled with a cell\u2010laden, three\u2010dimensional\u2010printed extracellular matrix coating containing a custom\u2010designed electronic mesh. After 14 days of culture, the embedded electrodes recorded spontaneous cardiac activity, while localized electrical stimulation affected the tissue, enabling pacing at controlled frequencies. Calcium imaging demonstrated spatial activation across the engineered tissue during pacing. This platform establishes a foundation for integrating real\u2010time monitoring and electronic functional regulation into engineered cardiac constructs and represents an initial step toward bioelectronic organ engineering.<\/jats:p>","DOI":"10.1002\/advs.78395","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:51:12Z","timestamp":1792727472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Engineering a Bioelectronic Hybrid Heart with Integrated Sensing and Electrical Modulation"],"prefix":"10.1002","author":[{"given":"Itai","family":"Cabilly","sequence":"first","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"The Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol Center for Regenerative Biotechnology Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadas","family":"Oved","sequence":"additional","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"The Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol Center for Regenerative Biotechnology Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Feiner","sequence":"additional","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Noor","sequence":"additional","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Yadid","sequence":"additional","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Flury","sequence":"additional","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Shapira","sequence":"additional","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"The Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol Center for Regenerative Biotechnology Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3153-9928","authenticated-orcid":false,"given":"Tal","family":"Dvir","sequence":"additional","affiliation":[{"name":"The Biotechnology Unit, Shmunis School of Biomedicine and Cancer Research, Faculty of Life Sciences Tel Aviv University  Tel Aviv Israel"},{"name":"The Center for Nanoscience and Nanotechnology Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol Center for Regenerative Biotechnology Tel Aviv University  Tel Aviv Israel"},{"name":"Sagol School for Neuroscience Tel Aviv University  Tel Aviv Israel"},{"name":"School of Biomedical Engineering, Faculty of Engineering Tel Aviv University  Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001412"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"A.Hart D. 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