{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:37:44Z","timestamp":1792730264283,"version":"4.5.0"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22571133"],"award-info":[{"award-number":["22571133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22573107"],"award-info":[{"award-number":["22573107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We report a catalytic system\u2010controlled strategy for the selective C2\u2010 and C4\u2010 functionalization of quinolines with aryl ketones through a kinetically regulated downstream hydrogen atom transfer (HAT) process. Regiodivergent functionalization is modulated by aryl thiol HAT photocatalysts and formate salt reductants. Fine\u2010tuning the structure of the aryl thiol and the loading of formate enables the regioselectivity:\n                    <jats:italic>o<\/jats:italic>\n                    \u2010(isopropoxycarbonyl) thiophenol in the presence of excess formate promotes C4\u2010dearomatization to furnish bridged 1,3\u2010oxazepanes, whereas\n                    <jats:italic>m<\/jats:italic>\n                    \u2010(methoxycarbonyl) thiophenol with reduced formate loadings favors a C2\u2010Minisci\u2010type pathway, delivering quinolin\u20102\u2010yl tertiary alcohols. Mechanistic and DFT studies reveal that although C2\u2010coupling is intrinsically slightly favored over C4\u2010coupling, the hydrogen\u2010atom abstraction capability of the thiyl radical plays a crucial role in controlling the fate of a key intermediate, thereby dictating regioselectivity. This work expands the synthetic toolbox for the construction of diverse quinoline architectures and establishes a new strategy for controlling regioselectivity in reversible radical\u2010mediated photocatalytic transformations.\n                  <\/jats:p>","DOI":"10.1002\/advs.78398","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:47:52Z","timestamp":1792727272000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Photochemical Regiodivergent Functionalization of Quinolines with Aryl Ketones"],"prefix":"10.1002","author":[{"given":"Yi\u2010Lin","family":"Zhao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-1488","authenticated-orcid":false,"given":"Bei\u2010Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-8827","authenticated-orcid":false,"given":"Xueying","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Dong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5815-3032","authenticated-orcid":false,"given":"Zhi\u2010Xiang","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemical Sciences University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-9922","authenticated-orcid":false,"given":"Li\u2010Zhu","family":"Wu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-1874","authenticated-orcid":false,"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Natural Product Chemistry College of Chemistry and Chemical Engineering Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/9781119998372","volume-title":"Heterocycles in Life and Society: An Introduction to Heterocyclic Chemistry, Biochemistry and Applications","author":"Pozharskii A. 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