{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T04:37:45Z","timestamp":1792730265178,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["advanced.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Advanced Science"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Pancreatic ductal adenocarcinoma (PDAC) remains refractory to immunotherapy, largely due to the dense fibrotic stroma that promotes immune evasion and restricts drug penetration. Here, we report a multifunctional biomimetic nanoplatform (RPm@CC\u2010LY) that simultaneously remodels the fibrotic tumor microenvironment and potentiates antitumor immunity. RPm@CC\u2010LY achieves efficient tumor accumulation and effectively attenuates fibrosis through sustained release of Transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2) inhibitor LY2157299 (LY). Concurrently, intracellular acid\u2010triggered degradation induces Cu\n                    <jats:sup>+<\/jats:sup>\n                    \u2010mediated Fenton\u2010like reactions and Ca\n                    <jats:sup>2+<\/jats:sup>\n                    overload, leading to oxidative stress, mitochondrial dysfunction, and tumor cell apoptosis. In parallel, RPm@CC\u2010LY reprograms tumor\u2010associated macrophages (TAMs) toward an M1 phenotype and enhances dendritic cell maturation, thereby promoting robust CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell infiltration. Notably, when combined with anti\u2013PD\u20101 (\u03b1PD1) therapy, RPm@CC\u2010LY induces a systemic immune response in mice. This work establishes a synergistic nanotherapeutic strategy that integrates fibrosis remodeling with ion interference therapy to overcome the immunotherapeutic barriers posed by fibrosis in PDAC.\n                  <\/jats:p>","DOI":"10.1002\/advs.78436","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:49:36Z","timestamp":1792727376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomimetic Nanoplatform for Fibrosis Remodeling and Anti\u2010PD\u20101 Potentiation via Cu\n                    <sup>+<\/sup>\n                    \/Ca\n                    <sup>2+<\/sup>\n                    Ion Dysregulation and TGF\u2010\u03b2 Inhibition in PDAC"],"prefix":"10.1002","author":[{"given":"Jianmei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu Sichuan People\u2018s Republic of China"},{"name":"Nuclear Physics and Medical Research Key Laboratory of Sichuan Province Sichuan University  Chengdu Sichuan People\u2018s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8056-0734","authenticated-orcid":false,"given":"Qinlong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu Sichuan People\u2018s Republic of China"},{"name":"Nuclear Physics and Medical Research Key Laboratory of Sichuan Province Sichuan University  Chengdu Sichuan People\u2018s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of High Altitude Medicine Center for High Altitude Medicine West China Hospital Sichuan University  Chengdu Sichuan People\u2018s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9709-0744","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu Sichuan People\u2018s Republic of China"},{"name":"Nuclear Physics and Medical Research Key Laboratory of Sichuan Province Sichuan University  Chengdu Sichuan People\u2018s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Biotherapy Cancer Center West China Hospital Sichuan University  Chengdu Sichuan People\u2018s Republic of China"},{"name":"Nuclear Physics and Medical Research Key Laboratory of Sichuan Province Sichuan University  Chengdu Sichuan People\u2018s Republic of 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