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Even though they are well characterized from the clinical and molecular point of view, there is a gap in studies aiming to understand distribution and dissemination risk in goat populations throughout the world. Considering this, we developed probe\u2010based qPCR tests and combined it with pedigree analysis to deepen the knowledge related to the distribution of both mutations in Brazilian Anglo\u2010Nubian population. This study revealed, for the first time, that the mutation associated with Mucopolysaccharidosis IIID is segregating in our country, expanding the knowledge of the worldwide distribution of this disease\u2010associated allele. Additionally, the combination of genotyping and pedigree analysis enabled the estimation of additional high\u2010confidence putative genotypes, contributing to the reduction of genotyping costs and highlighting a putative pathway associated with the introduction\/dissemination of the Mucopolysaccharidosis IIID\u2010associated allele in Brazil. These results can be considered as an initial basis for the proposition of a program to control\/eradicate mutations associated with genetic diseases in Brazilian goat populations.<\/jats:p>","DOI":"10.1002\/age.70107","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T10:40:21Z","timestamp":1776854421000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mucopolysaccharidosis IIID and Beta\u2010Mannosidosis in Brazilian Anglo\u2010Nubian Goats: Molecular and Genealogical Insights for the Development and Implementation of a Genetic Disease Eradication Program"],"prefix":"10.1002","volume":"57","author":[{"given":"Fl\u00e1via Caroline Moreira","family":"Bezerra","sequence":"first","affiliation":[{"name":"Center for Open Access Genomic Analysis (CALAnGO) Federal University of Vale of S\u00e3o Francisco (Univasf)  Petrolina Pernambuco Brazil"},{"name":"Postgraduate Program in 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