{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:48:35Z","timestamp":1782208115371,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The folded ear phenotype of Scottish Fold cats is associated with an autosomal dominant\n                    <jats:italic>TRPV4<\/jats:italic>\n                    variant (c.1024G&gt;T) linked to osteochondrodysplasia. Although genetic testing has been implemented to guide breeding, empirical evidence of its impact on allele frequency remains limited, and crossbreed investigations are lacking. Here, we evaluated longitudinal changes in\n                    <jats:italic>TRPV4<\/jats:italic>\n                    c.1024G&gt;T allele frequencies in Scottish Folds and surveyed the variant in 8610 cats from 14 breeds in Japan. Overall, between 2017 and 2024, the proportion of homozygous cats significantly declined (from 14.2% to 1.9%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas the frequency of heterozygous cats remained stable (39.3% vs. 51.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.74). The variant was identified primarily in Scottish Folds but was also detected in American Curls, Norwegian Forest Cats, Munchkins, and Minuets. Taken together, our results highlight that integrating\n                    <jats:italic>TRPV4<\/jats:italic>\n                    c.1024G&gt;T genotyping into breeding programs can effectively reduce the prevalence of this hereditary disorder, and they warrant the expansion of genetic testing to additional breeds.\n                  <\/jats:p>","DOI":"10.1002\/age.70118","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T02:50:01Z","timestamp":1778467801000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Evidence of a Recent Decline and Crossbreed Distribution of\n                    <i>TRPV4<\/i>\n                    c.1024G&gt;T Variant in Domestic Cats"],"prefix":"10.1002","volume":"57","author":[{"given":"Hisashi","family":"Ukawa","sequence":"first","affiliation":[{"name":"Genetic Testing Section Anicom Pafe Inc.  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Akashi","sequence":"additional","affiliation":[{"name":"Genetic Testing Section Anicom Pafe Inc.  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hinako","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Genetic Testing Section Anicom Pafe Inc.  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saaya","family":"Hiyoshi\u2010Kanemoto","sequence":"additional","affiliation":[{"name":"Research and Development Section Anicom Specialty Medical Institute Inc.  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Onishi","sequence":"additional","affiliation":[{"name":"Genetic Testing Section Anicom Pafe Inc.  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ataka","sequence":"additional","affiliation":[{"name":"Genetic Testing Section Anicom Pafe Inc.  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-3498","authenticated-orcid":false,"given":"Yuki","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Genetic Testing Section Anicom Pafe Inc.  Yokohama Kanagawa Japan"},{"name":"Research and Development Section Anicom Specialty Medical Institute Inc.  Yokohama Kanagawa Japan"},{"name":"Data Science Center Azabu University  Sagamihara Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009804"},{"key":"e_1_2_7_3_1","first-page":"112","article-title":"Further Data on Folded\u2010Ear Cats","volume":"2","author":"Dyte C. E.","year":"1973","journal-title":"Carnivore Genetics Newsletter"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2016.03.019"},{"key":"e_1_2_7_5_1","first-page":"2","article-title":"Congenital Bone Lesions in Cats With Folded Ears","volume":"14","author":"Jackson O. F.","year":"1975","journal-title":"Bulletin of the Feline Advisory Bureau"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1999.tb11672.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2020.11.018"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-021-02337-5"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X231211763"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.20-0299"},{"key":"e_1_2_7_11_1","first-page":"64","article-title":"Folded\u2010Ear Cats: Further Observations","volume":"2","author":"Todd N. B.","year":"1972","journal-title":"Carnivore Genetics Newsletter"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evad231"}],"container-title":["Animal Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/age.70118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/age.70118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/age.70118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:10:44Z","timestamp":1782205844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/age.70118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,10]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/age.70118"],"URL":"https:\/\/doi.org\/10.1002\/age.70118","archive":["Portico"],"relation":{},"ISSN":["0268-9146","1365-2052"],"issn-type":[{"value":"0268-9146","type":"print"},{"value":"1365-2052","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,10]]},"assertion":[{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70118"}}