{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:49:07Z","timestamp":1782208147262,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100016209","name":"Bilimsel Ara\u015ft\u0131rma Projeleri, Erciyes \u00dcniversitesi","doi-asserted-by":"publisher","award":["TSA\u20102022\u201011915"],"award-info":[{"award-number":["TSA\u20102022\u201011915"]}],"id":[{"id":"10.13039\/501100016209","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The growing demand for animal products, combined with declining livestock production due to urbanization and climate change, underscores the need for sustainable breeding strategies. In sheep production, liveweight and weight gain until weaning are key economic traits. Selection signature analyses have previously identified the\n                    <jats:italic>DIS3L2<\/jats:italic>\n                    gene, located on OAR2 (~233 Mbp), as a candidate under positive selection for body weight and morphology in sheep. However, its direct association with growth traits remained uninvestigated. This study explored the association between a splice region variant in the\n                    <jats:italic>DIS3L2<\/jats:italic>\n                    gene (rs421664828) and pre\u2010weaning growth traits in four indigenous sheep breeds in T\u00fcrkiye: Central Anatolian Merino, Karayaka, Akkaraman, and Morkaraman. A total of 1862 lambs from 10 herds were genotyped using a custom TaqMan Genotyping assay. Body weights were recorded at birth and on Days 30, 60, and 90, with average daily gain (ADG) calculated until weaning. The AG genotype was the most prevalent (92.1%), and all breeds deviated from Hardy\u2013Weinberg equilibrium. Association analysis revealed significant effects of rs421664828 on weight at Days 60 and 90 and on ADG\u201090. The AG genotype was consistently associated with higher growth performance. These findings support the use of\n                    <jats:italic>DIS3L2<\/jats:italic>\n                    \u2010rs421664828 in marker\u2010assisted selection to enhance growth traits in sheep.\n                  <\/jats:p>","DOI":"10.1002\/age.70126","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:50:09Z","timestamp":1780444209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Relationship Between Ovine Selection Signature\n                    <scp>DIS3<\/scp>\n                    Like 3\u2032\u20105\u2032 Exoribonuclease 2 (\n                    <i>DIS3L2<\/i>\n                    ) Gene and Weaning Weight and Average Daily Gain Until Weaning in Lambs"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-9830","authenticated-orcid":false,"given":"Bilal","family":"Aky\u00fcz","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Genetics Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5795-8859","authenticated-orcid":false,"given":"Fadime","family":"Daldaban","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Genetics Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1495-1248","authenticated-orcid":false,"given":"Davut","family":"Bayram","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Animal Science Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-1079","authenticated-orcid":false,"given":"Ferda","family":"Karaku\u015f","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Department of Animal Science Van University  Van T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6160-2484","authenticated-orcid":false,"given":"Mustafa","family":"\u00d6zdemir","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Department of Animal Science Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-9589","authenticated-orcid":false,"given":"Emre","family":"\u015eirin","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Department of Agricultural Biotechnology K\u0131r\u015fehir Ahi Evran University  K\u0131r\u015fehir T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2440-884X","authenticated-orcid":false,"given":"Korhan","family":"Arslan","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Department of Genetics Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5894-5072","authenticated-orcid":false,"given":"Mehmet Ulas","family":"Cinar","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Department of Animal Science Erciyes University  Kayseri T\u00fcrkiye"},{"name":"College of Veterinary Medicine, Department of Veterinary Microbiology and Pathology Washington State University  Pullman Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00699"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2022.110448"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5194\/aab\u201068\u2010357\u20102025"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010019\u20105811\u20101"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102796.2011.02450.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.2005.151"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1071"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1308113"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani9030075"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/atmos13010140"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0291805"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani10122391"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2017.01.006"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227254"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201063974\u20100"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001258"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2478\/aoas\u20102021\u20100024"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2020.06.011"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5713\/ab.23.0496"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335\u2010024\u201010075\u2010y"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13353\u2010025\u201000941\u2010z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11250\u2010022\u201003405\u20102"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2020.104257"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066048"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/age.13067"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jbg.12527"}],"container-title":["Animal 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