{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T09:23:29Z","timestamp":1787217809994,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012453","name":"China Agricultural Research System","doi-asserted-by":"publisher","award":["CARS\u201039\u201003"],"award-info":[{"award-number":["CARS\u201039\u201003"]}],"id":[{"id":"10.13039\/501100012453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The quality of cashmere fiber is fundamentally determined by the embryonic morphogenesis of hair follicles, a process highly dependent on the normal function of hair follicle stem cells (HFSCs). MicroRNAs (miRNAs) are key post\u2010transcriptional regulators, but their specific roles in cashmere goat hair follicle development remain unclear. In this study, we identified the differentially expressed miRNA, miR\u2010376c\u20103p, by analyzing transcriptomic data from embryonic skin (E65, E90, E120) of cashmere goats. Functional assays, including CCK8, crystal violet staining, clonogenic assay, and analysis of proliferation\/apoptosis\u2010related proteins (PCNA, CDK4, MKI67, BCL2, CAS3 and CAS9), demonstrated that miR\u2010376c\u20103p significantly inhibited HFSCs proliferation, induced apoptosis, and blocked the differentiation process, as evidenced by the downregulation of differentiation\u2010associated keratins (KRT4, KRT10, KRT14) and the upregulation of stemness maintenance factors (OCT4, NANOG, SOX9 and KRT15). Mechanistic investigations revealed that miR\u2010376c\u20103p directly bound to the 3\u2032UTR of\n                    <jats:italic>STRBP<\/jats:italic>\n                    mRNA and inhibited its expression, which was validated by a dual\u2010luciferase reporter assay. Conversely, overexpression of STRBP promoted HFSCs proliferation and differentiation. Further analysis found that STRBP functioned by activating the Wnt\/\u03b2\u2010catenin and BMP signaling pathways, whereas miR\u2010376c\u20103p inhibited these same pathways. In summary, this study elucidates a novel regulatory axis: miR\u2010376c\u20103p influencing the Wnt\/\u03b2\u2010catenin and BMP signaling cascades in HFSCs by targeting\n                    <jats:italic>STRBP<\/jats:italic>\n                    mRNA, thereby regulating cell fate. This research provides important insights into the molecular mechanisms of miRNA\u2010mediated hair follicle morphogenesis and stem cell biology in cashmere goats.\n                  <\/jats:p>","DOI":"10.1002\/age.70185","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:25:26Z","timestamp":1787214326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MiR<\/scp>\n                    \u2010376c\u20103p Targets\n                    <scp>\n                      <i>STRBP<\/i>\n                      mRNA\n                    <\/scp>\n                    to Regulate Cashmere Goat Hair Follicle Stem Cell Proliferation and Multipotency by Inhibiting the Wnt\/\u03b2\u2010Catenin and\n                    <scp>BMP<\/scp>\n                    Signaling 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