{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:08:02Z","timestamp":1788851282993,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20240101253JC"],"award-info":[{"award-number":["20240101253JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The Min pig, a representative northern Chinese indigenous breed, carries a unique ancestral background shaped by the historical phylogeography of Northeast Asia. This study aimed to dissect the population structure, temporal genetic divergence, and ancestral composition of Min pigs, trace their evolutionary origin, and identify trait\u2010linked functional genes, providing information regarding their evolutionary history and conservation. We analyzed 61 Min pigs sampled across nearly 20\u2009years and 701 reference pigs comprising other Chinese indigenous breeds, Western commercial lines, and Chinese wild boars, using PCA, NJ phylogenetic analysis, Admixture, TreeMix, D\u2010statistic, f4\u2010ratio, and combined selection signature scans (sliding\u2010window F\n                    <jats:sub>ST<\/jats:sub>\n                    , XP\u2010EHH, and \u03c0\u2010ratio). Clear genetic stratification was observed among Min pig subpopulations, reflecting long\u2010term divergence under natural and artificial selection. PCA and Admixture (\n                    <jats:italic>K<\/jats:italic>\n                    \u2009=\u20092\u20134) separated East Asian indigenous and Western ancestral components, verifying an admixed Northeast Asian origin with a dominant ancient East Asian component and a Western component. Compared with early\u20102000s Min pigs, contemporary individuals are genetically closer to Western breeds and exhibit a more scattered structure due to shifted ancestral component proportions, further confirmed by D\u2010statistic and f4\u2010ratio values. We identified 321 differentiated SNP loci based on the Animal QTL database, corresponding to core candidate genes (\n                    <jats:italic>AKT3<\/jats:italic>\n                    ,\n                    <jats:italic>ACACA<\/jats:italic>\n                    ,\n                    <jats:italic>MAP3K5<\/jats:italic>\n                    ,\n                    <jats:italic>FGFR4<\/jats:italic>\n                    ,\n                    <jats:italic>C3<\/jats:italic>\n                    , and\n                    <jats:italic>SERPINC1<\/jats:italic>\n                    ) enriched for meat quality, growth, reproduction, immunity, energy metabolism, and MAPK\/PI3K\u2010Akt\/AMPK pathways. This study reveals Min pigs' admixed origin and temporal divergence, clarifying their Northeast Asian evolution and providing molecular markers for genetic monitoring and conservation.\n                  <\/jats:p>","DOI":"10.1002\/age.70204","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:22:21Z","timestamp":1788848541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome Wide Analysis Reveals Divergence and Ancestral Origins of Min Pigs"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5727-0433","authenticated-orcid":false,"given":"Long","family":"Jin","sequence":"first","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyue","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Ning","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuyang","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1718-4717","authenticated-orcid":false,"given":"Changyi","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Bie","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0542-9477","authenticated-orcid":false,"given":"Hao","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8077-576X","authenticated-orcid":false,"given":"Boxing","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Animal Science Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3199"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.094052.109"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35052563"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.07.015"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2023.09.010"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btr330"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2006.3514"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomethods\/bpab017"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btae038"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0082-2"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaf214"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani14213123"},{"key":"e_1_2_13_16_1","first-page":"132","article-title":"Report on the Conservation and Breeding of Jilin Min Pigs","volume":"34","author":"Jin X.","year":"2017","journal-title":"Swine Industry Science"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.2527\/2005.83102255x"},{"key":"e_1_2_13_18_1","first-page":"139","volume-title":"Animal Breeding and Genetics","author":"Knap P. 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