{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:57:29Z","timestamp":1790654249136,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["20260102191JC"],"award-info":[{"award-number":["20260102191JC"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Animal Genetics"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Meat quality is a vital economic trait in geese and is largely determined by embryonic muscle development. Building on previously reported whole\u2010genome resequencing and breast muscle transcriptome data from Xianghai Flying (XHF) Goose and Zi Goose, two breeds with divergent meat quality,\n                    <jats:italic>f<\/jats:italic>\n                    <jats:italic>ib<\/jats:italic>\n                    <jats:italic>ulin<\/jats:italic>\n                    <jats:italic>\u2010<\/jats:italic>\n                    <jats:italic>1<\/jats:italic>\n                    (\n                    <jats:italic>FBLN1<\/jats:italic>\n                    ) was identified as a candidate gene showing both strong selection signals and significant differential expression.\n                    <jats:italic>FBLN1<\/jats:italic>\n                    was overexpressed and knocked down in primary goose embryonic myoblasts. Because no goose\u2010specific antibody is commercially available, all readouts were obtained at the mRNA level.\n                    <jats:italic>FBLN1<\/jats:italic>\n                    was found to promote myoblast proliferation and to accelerate the G1\/S cell cycle transition, with increased expression of\n                    <jats:italic>CCND1<\/jats:italic>\n                    and\n                    <jats:italic>CDK2<\/jats:italic>\n                    . Apoptosis was concurrently suppressed, accompanied by downregulation of\n                    <jats:italic>Bax<\/jats:italic>\n                    and upregulation of\n                    <jats:italic>Bcl\u20102<\/jats:italic>\n                    , whereas transcript levels of\n                    <jats:italic>Caspase\u20103<\/jats:italic>\n                    and\n                    <jats:italic>Caspase\u20109<\/jats:italic>\n                    remained unaltered. The mRNA levels of the myogenic differentiation markers\n                    <jats:italic>Myomaker<\/jats:italic>\n                    ,\n                    <jats:italic>MYOD1<\/jats:italic>\n                    , and\n                    <jats:italic>MYF5<\/jats:italic>\n                    were correspondingly affected. Bioinformatic analyses predicted FBLN1 to be an extracellular matrix protein that interacts with proteins implicated in muscle elasticity, tenderness, and juiciness. These findings suggest that\n                    <jats:italic>FBLN1<\/jats:italic>\n                    plays an important role in embryonic myoblast development and represents a valuable candidate gene for improving goose meat quality, thereby offering new perspectives for poultry molecular breeding.\n                  <\/jats:p>","DOI":"10.1002\/age.70214","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:26:12Z","timestamp":1790652372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>FBLN1<\/i>\n                    Regulates Embryonic Myoblast Proliferation and Differentiation in Geese: Functional Characterization of a Meat Quality\u2010Associated Candidate Gene From Prior Multi\u2010Omics Screening"],"prefix":"10.1002","volume":"57","author":[{"given":"Zongdi","family":"Li","sequence":"first","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2731-6837","authenticated-orcid":false,"given":"Hongyu","family":"Ni","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Lou","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingnan","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8013-4313","authenticated-orcid":false,"given":"Lin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Henan Academy of Agricultural Sciences  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3153-2981","authenticated-orcid":false,"given":"Xiaojun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Physical and Chemical Inspection Division Changchun Nanguan District Center for Disease Control and Prevention  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5342-0664","authenticated-orcid":false,"given":"Yonghong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2962-1399","authenticated-orcid":false,"given":"Yuwei","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science, Jilin University  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"4","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.semcdb.2005.07.006","article-title":"MyoD and the Transcriptional Control of Myogenesis","volume":"16","author":"Berkes C. 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