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This study aimed to characterize HRR patterns in five Kazakh sheep breeds using a publicly available OvineSNP50 genotyping dataset. After quality control, ~25 000 SNPs were retained for 1634 Akzhaiyk, 1089 Edilbay, 532 Kazakh Fine\u2010Wool, 932 Kazakh Semi\u2010Coarse, and 282 Saryarka sheep. HRR were detected separately in each breed using the sliding\u2010window approach in detectRUNS R package, with a minimum segment length of 250\u2009kb, at least 10 SNPs per window and segment, and a maximum of two opposing homozygous and one missing SNP per window. The average number of HRR per individual ranged from 40.75\u2009\u00b1\u20096.38 in Saryarka to 54.75\u2009\u00b1\u20097.34 in Kazakh Fine\u2010Wool sheep. HRR lengths ranged from 259.07\u2009kb to 3.26\u2009Mb, with an average of 0.7\u2009Mb across breeds. Seventeen HRR islands, defined as regions shared by HRR in at least 25% of individuals within a breed, were identified, including regions on chromosomes 8 and 17 shared across all breeds. Genes overlapping these islands were associated with cellular homeostasis, immunity, metabolism, growth, and stress response, while the HRR islands overlapped with QTL associated with health, wool characteristics, and reproduction. These findings highlight the potential of HRR analysis to identify candidate genomic regions relevant to adaptation and economically important traits, providing insights for the conservation and genetic improvement of Kazakh sheep populations.<\/jats:p>","DOI":"10.1002\/age.70219","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:20:47Z","timestamp":1792038047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010Wide Characterization of Heterozygosity\u2010Rich Regions in Kazakh Native Sheep Breeds"],"prefix":"10.1002","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0615-7880","authenticated-orcid":false,"given":"Sholpan","family":"Bakhtybekkyzy","sequence":"first","affiliation":[{"name":"Laboratory of Animal Genetics and Cytogenetics, RSE Institute of Genetics and Physiology, Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5085-8561","authenticated-orcid":false,"given":"Zarina","family":"Orazymbetova","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Cytogenetics, RSE Institute of Genetics and Physiology, Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2871-1552","authenticated-orcid":false,"given":"Aizhan","family":"Mussayeva","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Cytogenetics, RSE Institute of Genetics and Physiology, Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7301-6626","authenticated-orcid":false,"given":"Aidana","family":"Bekitayeva","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Genetics and Cytogenetics, RSE Institute of Genetics and Physiology, Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6455-4526","authenticated-orcid":false,"given":"Ajoy","family":"Mandal","sequence":"additional","affiliation":[{"name":"Animal Breeding Section ICAR\u2010National Dairy Research Institute, Eastern Regional Station  Kalyani India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2437-6005","authenticated-orcid":false,"given":"Hasan","family":"Baneh","sequence":"additional","affiliation":[{"name":"Center for Bio\u2010 and Medical Technologies Skolkovo Institute of Science and Technology (Skoltech)  Moscow Russia"},{"name":"Animal Science Research Department Kurdistan Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO)  Sanandaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864\u2010019\u20106079\u20101"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13071\u2010015\u20100715\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14111988"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fanim.2024.1468575"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00207454.2019.1694020"},{"key":"e_1_2_10_7_1","first-page":"7","article-title":"Improvement of the Kazakh Fine\u2010Wool Sheep Breed at the Mynbaev Experimental Station","volume":"4","author":"Balmont V. 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