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Characterized by progressive neurodegeneration, the disease is expressed as gradual memory loss together with decline in cognitive abilities and other brain functions. Despite extensive research over the past decade, the cause and cure of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> both remain largely unknown. Several <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\u2010associated deficits have been targeted for interventions, including those based on amyloid\u2010beta, tau, and inflammation hypotheses. Only 2 types of medications\u2014cholinesterase inhibitors and memantine\u2014have been approved, to control the cognitive symptoms of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> such as the loss of memory, language, and executive function. Noninvasive in\u00a0vivo functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>) technologies, including the blood oxygen level\u2010dependent functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, arterial spin labeling\u2010based perfusion <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>, and the proton magnetic resonance spectroscopy have been used to study the effect of Ch<jats:styled-content style=\"fixed-case\">EI<\/jats:styled-content>s and memantine in the brain. Most of these studies have demonstrated increased functional activation and connectivity, increased regional brain blood flow and volume post\u2010treatment, and positive responses of critical brain metabolites reflecting neuronal status and functionality in patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and mild cognitive impairment. The findings have contributed to the understanding of the mechanisms underlying the medication treatments and support the crucial role of functional <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> technologies in the development and refinement of <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> medication therapies.<\/jats:p>","DOI":"10.1002\/agm2.12017","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T09:54:42Z","timestamp":1524477282000},"page":"75-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Functional <scp>MRI<\/scp> technologies in the study of medication treatment effect on Alzheimer's disease"],"prefix":"10.1002","volume":"1","author":[{"given":"Hui","family":"Guo","sequence":"first","affiliation":[{"name":"SFU ImageTech Laboratory Surrey Memorial Hospital Surrey BC Canada"},{"name":"Health Sciences and Innovation Surrey 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