{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:13:02Z","timestamp":1774624382627,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>It is unclear how alterations in gray matter volume and white matter density affect elderly patients with irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). This study aimed to investigate the relationship between structural changes in the brain and psychological stress in elderly <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients and 12 healthy controls underwent structural magnetic resonance imaging. Voxel\u2010based morphometry and diffusion tensor imaging analysis were used to identify abnormalities in cortical regions and white matter, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> group showed a significant <jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content> reduction in the cingulate gyrus, occipital lobe, hippocampus, frontal lobe, medial frontal gyrus, superior frontal gyrus, and limbic lobe as well as a higher <jats:styled-content style=\"fixed-case\">GMV<\/jats:styled-content> in the insula, superior temporal gyrus, angular gyrus, and supramarginal gyrus. Diffusion tensor imaging indicated that the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> group had lower fractional anisotropy in the corpus callosum, upper corona, fornix, internal capsule, and brainstem. Additionally, <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients showed higher mean diffusivity in the cingulate gyrus, corpus callosum, upper corona, internal capsule, external capsule, fornix, and superior longitudinal fasciculus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Structural changes in the brain play a role in the condition of elderly <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> patients. Psychological stress is an important factor for developing <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> via the hypothalamic\u2010pituitary\u2010adrenal axis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/agm2.12034","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T07:19:55Z","timestamp":1537773595000},"page":"141-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Microstructural changes in the brain in elderly patients with irritable bowel syndrome"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8559-7165","authenticated-orcid":false,"given":"Lanlan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Gerontology Huashan Hospital Shanghai Medical College Fudan University Shanghai 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