{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:57:30Z","timestamp":1787846250224,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to analyze the sensitivity and specificity of a shortened Hasegawa Dementia Scale Revised (shortened HDS\u2010R) questionnaire and explore its utility for the rapid screening and diagnosis of Alzheimer\u2019s disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 113 patients over the age of 60\u00a0years who visited our hospital from June 2018 to January 2021 including 70 subjects with AD and 43 healthy subjects. AD was diagnosed in accordance with the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, and the standard HDS\u2010R questionnaire was used as a neuropsychological examination. The shortened HDS\u2010R questionnaire was composed of the first seven subdomains (1 to 7) of the HDS\u2010R questionnaire and excluded subdomains 8 and 9. Magnetic resonance imaging (MRI) was performed to calculate the degree of atrophy of the whole brain, hippocampus, and parahippocampal gyrus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative contribution ratio of subdomains 1 to 7 of the HDS\u2010R questionnaire was as high as 94%, indicating that the construct validity of the shortened HDS\u2010R was very good. The correlation coefficient of the total scores of the shortened HDS\u2010R and the HDS\u2010R was 0.96, indicating that the criterion\u2010related validity was also very good. Furthermore, the shortened HDS\u2010R was significantly negatively correlated with the degree of atrophy in the whole brain, hippocampus, and parahippocampal gyrus, indicating that its concurrent validity was very good in relation to imaging parameters. Cronbach\u2019s \u03b1 coefficient of the shortened HDS\u2010R was 0.76, and the correlation coefficient of the item\u2010total correlation analysis was between 0.68 and 0.76, indicating that this questionnaire has high internal consistency and reliability. The total shortened HDS\u2010R score of the normal group (17.0\u00a0\u00b1\u00a01.9) was significantly higher than that of the AD group (8.6\u00a0\u00b1\u00a03.8), demonstrating that the total shortened HDS\u2010R score can be used to identify healthy individuals and patients with AD. When the cutoff score was 14 of 15, the sensitivity was 92.9% and the specificity was 88.4%. The diagnostic ability of the shortened HDS\u2010R was 91.2%, which indicates that it is similar to the full HDS\u2010R questionnaire as an AD screening tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As a neuropsychological examination questionnaire for the screening and diagnosis of AD, the shortened HDS\u2010R had very high validity and reliability. Its sensitivity, specificity, and diagnostic ability were similar to those of the gold standard HDS\u2010R; therefore, it can be considered a concise and useful questionnaire for AD screening and diagnosis in the older population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/agm2.12152","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T12:58:25Z","timestamp":1623243505000},"page":"109-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Utility of a shortened Hasegawa Dementia Scale Revised questionnaire to rapidly screen and diagnose Alzheimer\u2019s disease"],"prefix":"10.1002","volume":"4","author":[{"given":"Qian","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Medicine Okamotoishii Hospital Shizuoka Japan"},{"name":"Department of Geriatric Medicine University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Medicine Okamotoishii Hospital Shizuoka Japan"},{"name":"Department of Geriatric Medicine University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouka","family":"Numata","sequence":"additional","affiliation":[{"name":"Department of Medicine National Hospital Organization Tokyo Medical Center Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Xie","sequence":"additional","affiliation":[{"name":"Chasuqi Cilao Clinic of Huhhot Huhhot China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Medicine Okamotoishii Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Alzheimer\u2019s Association Alzheimer\u2019s Disease Facts & Figures.https:\/\/www.alz.org\/alzheimer_s_dementia"},{"key":"e_1_2_9_3_1","unstructured":"Aging Health Network January 13 2020."},{"key":"e_1_2_9_4_1","unstructured":"Ministry of Health Labour and Welfare White Book 2016."},{"key":"e_1_2_9_5_1","unstructured":"Ministry of Health Labour and Welfare: Comprehensive strategy for the promotion of dementia policy\u2010Building a community suitable for the elderly with dementia 2017."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1992.tb01992.x"},{"key":"e_1_2_9_7_1","first-page":"1339","article-title":"Development of Hasegawa Dementia Scale Revised (HDS\u2010R)","volume":"2","author":"Katou S","year":"1991","journal-title":"Japanese J Geriatr Psychiatry"},{"key":"e_1_2_9_8_1","volume-title":"Comprehensive Diagnosis and Treatment Methods and Rehabilitation for the Elderly","author":"Outi Y","year":"2006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.2152"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000084558"},{"issue":"2","key":"e_1_2_9_12_1","first-page":"104","article-title":"Relationship among hippocampal atrophy, brain blood flow, and neuropsychological tests in patients who experienced forgetfulness","volume":"8","author":"Bizen H","year":"2017","journal-title":"JAHS"},{"key":"e_1_2_9_13_1","unstructured":"Japanese Society of Geriatrics homepage.https:\/\/www.jpn\u2010geriat\u2010soc.or.jp\/tool\/tool_02"},{"key":"e_1_2_9_14_1","unstructured":"American Psychiatric Association: Diagnostic and statistical manual of mental disorders: DSM\u2010IV [Internet]. 4th ed. 1994. 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