{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:58:01Z","timestamp":1790636281373,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Persons with dementia commonly experience a range of beh<jats:bold>avioural and psychological symptoms, including agitation, aggression, perceptual disturbances, and depression. While psychotropic medications are<\/jats:bold>regularly prescribed to mitigate these symptoms, these agents also carry a broad adverse effect profile. This study aimed to characterize psychotropic medication use in patients with dementia, as well as identify prescribing factors associated with falls in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study collected longitudinal demographic and medication data from all patients admitted to a neuro\u2010cognitive unit at an Australian metropolitan hospital over a 2\u2010year period. Psychotropic polypharmacy and psychotropic agent use per patient\u2010fortnight were investigated for their association with inpatient falls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients (n\u00a0=\u00a0147) were prescribed at least one psychotropic medication, with 96% receiving anti\u2010psychotic medications and 90% receiving benzodiazepines. Patient fall rate was significantly associated with anticholinergic drug use (Incidence rate ratio: 2.2;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), as well as concomitant use of \u22655 daily psychotropic agents (Incidence rate ratio: 3.1;<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with dementia are routinely prescribed a wide variety of psychotropic medications. Use of anticholinergic drugs and psychotropic polypharmacy are correlated with fall incidence in persons with dementia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/agm2.12175","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T06:40:48Z","timestamp":1630132848000},"page":"193-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["A delicate balance: Psychotropic polypharmacy and anti\u2010cholinergic use are correlated with fall incidence in Australian inpatients with dementia"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2343-1378","authenticated-orcid":false,"given":"Samuel X.","family":"Tan","sequence":"first","affiliation":[{"name":"Princess Alexandra Hospital Brisbane QLD Australia"},{"name":"The Prince Charles Hospital Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah 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