{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:26:38Z","timestamp":1786976798998,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC2000301"],"award-info":[{"award-number":["2018YFC2000301"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the morphological changes with age in the pancreases of healthy individuals undergoing magnetic resonance imaging (MRI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The participants were selected from adults who were undergoing physical examinations from January 2017 to September 2020 at Huadong Hospital. They were divided according to age, as broken down by decades into seven\u00a0groups ranging from 20 to 29\u00a0years to \u226580\u00a0years of age. There were 30 to 35 cases for each decade. They were then divided into a young and middle\u2010aged group (&lt;60\u00a0years of age) and an elderly group (\u226560\u00a0years of age). The morphological characteristics of the pancreases of each participant in the group were measured on magnetic resonance images. The characteristics included the pancreatic anteroposterior diameters and volumes. The relationships between the anteroposterior diameters of the pancreatic head, body, and tail and pancreatic volume and age were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 226\u00a0magnetic resonance images from 112 (49.56%) men and 114 (50.44%) women, aged 22\u201393 (54.68\u00a0\u00b1\u00a019.52) years. The age ranges of the seven\u00a0groups consisted of the following: 20\u201329\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a033), 30\u201339\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032), 40\u201349\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a032), 50\u201359\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a031), 60\u201369\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a035), 70\u201379\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a033) and \u226580\u00a0years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a030). The age range and numbers of patients in the young and middle\u2010aged group was 22\u201359 (40.09\u00a0\u00b1\u00a010.88) years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0128) and in the elderly group was 60\u201393 (73.74\u00a0\u00b1\u00a08.99) years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a098). The MRI findings characteristic of aging included pancreatic atrophy (especially of the pancreatic tail), pancreatic lobulation, uneven signal intensity, fatty degeneration, and widening of the main pancreatic duct. The respective anteroposterior diameters of the pancreatic head, body, and tail and the pancreatic volumes peaked at 30 to 39\u00a0years as follows: 28.03\u00a0\u00b1\u00a04.45\u00a0mm, 24.10\u00a0\u00b1\u00a04.27\u00a0mm, 24.57\u00a0\u00b1\u00a04.94\u00a0mm, 98.54\u00a0\u00b1\u00a026.56\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ; and then gradually decreased to 19.05\u00a0\u00b1\u00a03.59\u00a0mm, 16.00\u00a0\u00b1\u00a03.81\u00a0mm, 13.83\u00a0\u00b1\u00a03.39\u00a0mm, 45.02\u00a0\u00b1\u00a09.15\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      at \u226580\u00a0years, for respective decreases of 32.03%, 33.60%, 43.71%, and 54.31%. The respective anteroposterior diameters of the pancreatic head, body, tail, and pancreatic volume in the elderly patients were 21.45\u00a0\u00b1\u00a04.15\u00a0mm, 18.14\u00a0\u00b1\u00a04.09\u00a0mm, 16.81\u00a0\u00b1\u00a04.37\u00a0mm, and 59.02\u00a0\u00b1\u00a021.44\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      , which were significantly smaller than the respective corresponding measurements in the young and middle\u2010aged patients (26.09\u00a0\u00b1\u00a04.40\u00a0mm, 22.30\u00a0\u00b1\u00a04.42\u00a0mm, 22.08\u00a0\u00b1\u00a04.53\u00a0mm, and 88.32\u00a0\u00b1\u00a023.92\u00a0cm\n                      <jats:sup>3<\/jats:sup>\n                      ). The differences were statistically significant (t\u00a0=\u00a08.06, 7.24, 8.79, 9.54, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). The anteroposterior diameters of the pancreatic head, body, tail, and pancreatic volume were negatively correlated with age (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.53, \u22120.47, \u22120.56, \u22120.57, respectively,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The anteroposterior diameters of the pancreatic head, body, tail, and the pancreatic volume all peaked at the age range of 30\u201339\u00a0years and then gradually decreased with increasing age. After the age of 60\u00a0years, pancreatic atrophy became increasingly obvious, with changes in shape and widening with age of the main pancreatic duct.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/agm2.12185","type":"journal-article","created":{"date-parts":[[2021,12,12]],"date-time":"2021-12-12T00:40:15Z","timestamp":1639269615000},"page":"297-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Magnetic resonance imaging investigation of age\u2010related morphological changes in the pancreases of 226 Chinese"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3681-9769","authenticated-orcid":false,"given":"Lu","family":"Wang","sequence":"first","affiliation":[{"name":"The Department of Geriatrics and Gastroenterology Huadong Hospital Affiliated to Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Jia","sequence":"additional","affiliation":[{"name":"MRI Center Huadong Hospital Affiliated to Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwu","family":"Lin","sequence":"additional","affiliation":[{"name":"MRI Center Huadong Hospital Affiliated to Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbai","family":"Zheng","sequence":"additional","affiliation":[{"name":"The Department of Geriatrics and Gastroenterology Huadong Hospital Affiliated to Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01885094"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80294-4"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-012-0988-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.07.014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1355767"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(89)72760-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(98)70129-4"},{"issue":"1","key":"e_1_2_9_9_1","first-page":"48","article-title":"Pancreatic senescence and its clinical manifestations","volume":"3","author":"Wang L","year":"2020","journal-title":"Aging Med 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