{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:01:16Z","timestamp":1770156076077,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,12,24]],"date-time":"2023-12-24T00:00:00Z","timestamp":1703376000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>It is now recognized that blood brain barrier (BBB) leakage occurs in cerebral small vascular disease (CSVD) and plays a significant role in the pathophysiology of vascular dementia. We hypothesized that genetic polymorphisms of junctional adhesion molecule\u2010A (JAM\u2010A) (which may result in compromised structure of tight junction proteins that form the BBB) in combination with cerebrovascular risk factors hypertension, lipid disorders, and type 2 diabetes may result in BBB leakage and increase the individual's risk of CSVD\u2010related dementia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2013control study, 97 controls with a mean Mini\u2010Mental State Exam (MMSE) score of 29 and 38 CSVD\u2010related vascular dementia participants (mean MMSE score of 19) were recruited. Bloods were collected for the analysis of two common single nucleotide polymorphisms (SNPs) of the JAM\u2010A genotypes rs790056 and rs2481084 using real\u2010time polymerase chain reaction (PCR) assay. Medical history of hypertension, hyperlipidemia, and diabetes was collected for all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Polymorphisms of genotype JAM\u2010A SNP rs790056 showed statistically significant result when the subgroup with hyperlipidemia was analyzed (OR\u2009=\u20093.130, <jats:italic>p<\/jats:italic>\u2009=\u20090.042 for TC\u2009+\u2009CC genotypes with hyperlipidaemia vs controls). Similar result was found with diabetes (OR\u2009=\u20094.670, <jats:italic>p<\/jats:italic>\u2009=\u20090.031 for TC\u2009+\u2009CC genotypes vs controls). No significant result was found with hypertension. Borderline results of statistical significance were found for JAM\u2010A SNP rs2481084 with hyperlipidemia (OR\u2009=\u20093.210, <jats:italic>p<\/jats:italic>\u2009=\u20090.054 for TC\u2009+\u2009CC genotypes vs controls) and with diabetes (OR\u2009=\u20093.620, <jats:italic>p<\/jats:italic>\u2009=\u20090.069 for TC\u2009+\u2009CC genotypes vs controls) but not for hypertension. The borderline results might have been due to lack of statistical power because of small sample size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results lend further support that cerebrovascular risk factors interact with genetic polymorphisms of BBB proteins to increase the risk of vascular dementia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/agm2.12278","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T07:34:26Z","timestamp":1703489666000},"page":"347-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Involvement of single nucleotide polymorphisms of junction adhesion molecule with small vessel vascular dementia"],"prefix":"10.1002","volume":"6","author":[{"given":"Peter","family":"Xie","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Kancherla","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sashiruben","family":"Chandramohan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0497-5572","authenticated-orcid":false,"given":"Nady","family":"Braidy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"Ingham Institute  Liverpool New South Wales Australia"},{"name":"Centre for Healthy Brain Ageing, School of Psychiatry University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice Kar Wing","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Western Sydney University  Macarthur New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying Hua","family":"Xu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"Ingham Institute  Liverpool New South Wales Australia"},{"name":"Department of Aged Care and Rehabilitation Bankstown Hospital  Bankstown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0481-3933","authenticated-orcid":false,"given":"Daniel K. Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of New South Wales  Sydney New South Wales Australia"},{"name":"Ingham Institute  Liverpool New South Wales Australia"},{"name":"Department of Aged Care and Rehabilitation Bankstown Hospital  Bankstown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00463-8"},{"key":"e_1_2_10_3_1","unstructured":"Mayo Clinic.Vascular dementia symptoms & causes.https:\/\/www.mayoclinic.org\/diseases\u2010conditions\/vascular\u2010dementia\/symptoms\u2010causes\/syc\u201020378793(Accessed July 10 2023)."},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12558"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.09.006"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000058480.77236.B3"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519885"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.07.015"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.50.4.966"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109005200"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183298"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-008-0364-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06678-11"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12747"},{"key":"e_1_2_10_15_1","unstructured":"https:\/\/www.broadinstitute.org\/haploview\/haploview(accessed July 10 2023)."},{"key":"e_1_2_10_16_1","unstructured":"https:\/\/gaow.github.io\/genetic\u2010analysis\u2010software\/f\/finetti\/(accessed July 10 2023)."},{"key":"e_1_2_10_17_1","unstructured":"StaroscikA.Hardy\u2010Weinberg Equilibrium Calculator.http:\/\/scienceprimer.com\/hardy\u2010weinberg\u2010equilibrium\u2010calculator(accessed July 10 2023)."},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.23"}],"container-title":["AGING MEDICINE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/agm2.12278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T07:41:04Z","timestamp":1705909264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/agm2.12278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/agm2.12278"],"URL":"https:\/\/doi.org\/10.1002\/agm2.12278","archive":["Portico"],"relation":{},"ISSN":["2475-0360","2475-0360"],"issn-type":[{"value":"2475-0360","type":"print"},{"value":"2475-0360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}