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Icariin (ICA) is the main active ingredient of Epimedium and has exhibited multiple bioactivities, such as anti\u2010tumor, neuroprotective, antioxidant, anti\u2010inflammatory, and anti\u2010aging properties. ICA could extend healthspan in both invertebrate and vertebrate models. In this review, the roles of ICA in protection from declined reproductive function, neurodegeneration, osteoporosis, aging intestinal microecology, and senescence of cardiovascular system will be summarized. Furthermore, the underlying mechanisms of ICA\u2010mediated anti\u2010aging effects will be introduced. Finally, we will discuss some key aspects that constrain the usage of ICA in clinical practice and the corresponding strategies to solve these issues.<\/jats:p>","DOI":"10.1002\/agm2.12284","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T07:29:11Z","timestamp":1708068551000},"page":"90-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010aging effects of icariin and the underlying mechanisms: A mini\u2010review"],"prefix":"10.1002","volume":"7","author":[{"given":"Ying","family":"Li","sequence":"first","affiliation":[{"name":"Department of Hematology Changchun Central Hospital  Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7008-6933","authenticated-orcid":false,"given":"Zhi\u2010Feng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Hospital of Jilin 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