{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:18:59Z","timestamp":1747145939726,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to investigate the retinal morpho\u2010functional characteristics of patients with neovascular wet age\u2010related macular degeneration (nAMD) treated with intravitreal injection (IV) of aflibercept (AFL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study was conducted on 35 patients previously diagnosed with type 1 nAMD who received a fixed\u2010dosing regimen of aflibercept injections over 12\u2009months. The goal was to assess trends in visual abilities over time by measuring visual acuity (VA), contrast sensitivity (CS), visual evoked potentials (VEPs), and spectral domain\u2010optical coherence tomography (SD\u2010OCT). The same psychophysical, electro\u2010functional, and morphological tests administered at baseline (T0) were repeated 4 to 8\u2009weeks after the last aflibercept injection (Tn), resulting in a total of six examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At Tn, all subjects exhibited improved VA for both far and near distances compared to values detected at T0. Similarly, VEP amplitude and latency values at Tn showed a greater P100 improvement than those observed at T0. Additionally, the CS examination at Tn demonstrated improvement, particularly at high spatial stimulation frequencies. The Tn SD\u2010OCT results highlighted a reduction in macular thickness compared to T0 values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This exploratory research indicates that intravitreal injections of AFL, following a fixed\u2010dosing regimen, represent a valuable therapeutic approach for enhancing visual performance. This conclusion is supported by comprehensive statistical analysis of psychophysical, electro\u2010functional, and morphological examinations within the same group of patients with nAMD, as demonstrated for the first time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/agm2.12296","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T09:19:01Z","timestamp":1712654341000},"page":"189-201","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychophysical, electrofunctional, and morphological evaluation in na\u00efve neovascular <scp>AMD<\/scp> patients treated with intravitreal <scp>anti\u2010VEGF<\/scp>"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5512-0849","authenticated-orcid":false,"given":"Marcella","family":"Nebbioso","sequence":"first","affiliation":[{"name":"Department of Sense Organs, Faculty of Medicine and Odontology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Franzone","sequence":"additional","affiliation":[{"name":"Ophthalmic Hospital, Medicine and Surgery University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Milanese","sequence":"additional","affiliation":[{"name":"Department of Public Health and Infectious Disease Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Artico","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Faculty of Medicine and Odontology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samanta","family":"Taurone","sequence":"additional","affiliation":[{"name":"Department of Movement, Human and Health Sciences University of Rome Foro Italico  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"La\u00a0Cava","sequence":"additional","affiliation":[{"name":"Department of Sense Organs, Faculty of Medicine and Odontology Sapienza University of Rome  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Livani","sequence":"additional","affiliation":[{"name":"S. 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