{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:45:45Z","timestamp":1790739945597,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T00:00:00Z","timestamp":1723852800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study is to understand the role of vitamin B12 supplementation in improving skeletal muscle function among the elderly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A literature review in the Medline database was conducted to understand the association between vitamin B12 and muscle function in Section A. In Section B, 28 healthy elderly participants aged \u226560\u2009years were recruited in a cross\u2010sectional design for estimation of plasma vitamin B12 status and assessment of upper limb muscle strength Maximal voluntary contraction (MVC) and muscle quality (expressed as MVC\/total muscle mass). Participants were grouped based on vitamin B12 status into vitamin B12\u2010depleted (&lt;148\u2009pmol\/L) and replete (\u2265148\u2009pmol\/L) groups. In a quasi\u2010experimental study design, the vitamin B12\u2010depleted group (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200914) received daily oral vitamin B12 supplementation of 100\u2009\u03bcg for 3\u2009months. All the study measures were repeated post\u2010supplementation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Vitamin B12 deficiency was identified to contribute adversely to muscle strength, quality, and physical performance among older people in the extensive literature review. The pilot intervention study showed significant improvement in MVC and muscle quality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.050) post\u2010vitamin B12 supplementation, comparable to the vitamin B12\u2010replete group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Vitamin B12 may have a crucial role in the maintenance of muscle function. 3\u2010month oral vitamin B12 supplementation among subclinical vitamin B12 deficient elderly improved muscle strength and quality and reached levels similar to the vitamin B12 replete group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/agm2.12346","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T03:20:03Z","timestamp":1723864803000},"page":"480-489","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Vitamin\n                    <scp>B12<\/scp>\n                    status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin\n                    <scp>B12<\/scp>\n                    supplementation in improving muscle function"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-6587","authenticated-orcid":false,"given":"Sowmya","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Physiology St. John's Medical College  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Bhadra","sequence":"additional","affiliation":[{"name":"Division of Clinical Physiology, Department of Physiology St. John's Medical College &amp; St. John's Research Institute  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumithra","family":"Selvam","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Biostatistics and Population Health St John's Research Institute  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucharita","family":"Sambashivaiah","sequence":"additional","affiliation":[{"name":"Department of Physiology St. John's Medical College  Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00059814"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2015.03.013"},{"key":"e_1_2_11_4_1","first-page":"1103","article-title":"National program of health\u2010care for the elderly in India: a hope for healthy ageing","volume":"4","author":"Verma R","year":"2013","journal-title":"Int J Prev Med"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000134362.76653.b2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2018.07.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11556-012-0102-8"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28047"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.1.72"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-018-1139-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1768_18"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.707036"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874609809666160211125218"},{"key":"e_1_2_11_14_1","unstructured":"CorichiM.Eight\u2010in\u2010ten Indians limit meat in their diets and four\u2010in\u2010ten consider themselves vegetarian.Pew Research Center.2021. 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