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Although conventional approaches have focused on the paramagnetic properties of iron, emerging and promising research has highlighted the significance of diamagnetic signatures associated with beta\u2010amyloid (A\u03b2) plaques and Tau (\u03c4) protein aggregates. Quantitative susceptibility mapping (QSM) is a complex post\u2010processing technique that visualizes and characterizes these subtle alterations in brain border tissue composition, such as the gray\u2013white matter interface. Through voxel\u2010wise separation of the contributions of diamagnetic and paramagnetic sources, QSM enabled the identification and quantification of A\u03b2 and \u03c4 aggregates, even in the presence of iron. However, several challenges remain in utilizing diamagnetic signatures of A\u03b2 and \u03c4 for clinical applications. These include the relatively small magnitude of the diamagnetic signal compared to paramagnetic iron, the need for high\u2010resolution imaging and sophisticated analysis techniques, and the standardization of QSM acquisition and analysis protocols. Further research is necessary to refine QSM techniques, optimize acquisition parameters, and develop robust analysis pipelines to improve the sensitivity and specificity of detecting the diamagnetic nature of A\u03b2 and \u03c4 aggregates. As our understanding of the diamagnetic properties of A\u03b2 and \u03c4 continues to evolve, QSM is expected to play a pivotal role in advancing our knowledge of AD and other neurodegenerative diseases.<\/jats:p>","DOI":"10.1002\/agm2.70006","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:45:18Z","timestamp":1739259918000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Diamagnetic Signature of Beta\u2010Amyloid (A\u03b2) and Tau (\u03c4) Tangle Pathology in Alzheimer's Disease: A Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1334-8826","authenticated-orcid":false,"given":"Sadegh","family":"Ghaderi","sequence":"first","affiliation":[{"name":"Neuromuscular Research Center, Department of Neurology, Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Neuroscience and Addiction Studies, 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