{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T08:07:14Z","timestamp":1783843634131,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the lymph node metastasis (LNM) pattern of esophageal squamous cell carcinoma (ESCC) and identify factors associated with LNM:<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study was conducted including 388 patients with ESCC who underwent curative resection at the First Affiliated Hospital of Nanjing Medical University between January 2020 and December 2022. Clinicopathological characteristics and lymph node metastasis patterns were analyzed. Univariate and multivariate analyses were performed to identify factors associated with LNM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 388 patients, 144 (37.11%) had lymph node metastasis. The total number of dissected lymph nodes was 8546, with 341 positive nodes, yielding an LNM degree of 3.99%. Upper thoracic ESCC was more likely to metastasize to upper right paratracheal lymph nodes, while lower thoracic ESCC showed a higher rate of paracardial lymph node metastasis. Tumor differentiation, tumor size, invasion depth, age, and intravascular tumor thrombus were associated with LNM. Multivariate logistic regression analysis revealed that tumor diameter \u2265\u20093\u2009cm (OR\u2009=\u20092.485, 95% CI 1.483\u20134.165,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and intravascular tumor thrombus (OR\u2009=\u20097.123, 95% CI 3.101\u201316.362,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) were independent risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Upper esophageal SCC tends to metastasize to upper mediastinal lymph nodes, whereas abdominal and paracardial lymph node metastasis is more common in lower esophageal SCC. Tumor size and intravascular tumor thrombus are independent risk factors for lymph node metastasis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/agm2.70096","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:18:51Z","timestamp":1782577131000},"page":"229-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lymph Node Metastasis Pattern and Influencing Factors in Esophageal Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"9","author":[{"given":"Yuheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4601-2789","authenticated-orcid":false,"given":"Jinhua","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.05.054"},{"key":"e_1_2_14_4_1","first-page":"2461","article-title":"Epidemiologic Risk Factors for Esophageal Cancer Development","volume":"12","author":"Mao W. M.","year":"2011","journal-title":"Asian Pacific Journal of Cancer Prevention: APJCP"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010012\u20102659\u2010x"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.07.006"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.129"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748\u2010013\u20100237\u20101"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21663"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442\u20102050.2001.00160.x"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S182436"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezaa371"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.03.093"},{"key":"e_1_2_14_14_1","first-page":"690","article-title":"Lymph Node Metastasis and Prognostic Factors for T1 Esophageal Cancer","volume":"55","author":"Duan X. F.","year":"2017","journal-title":"Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13019\u2010021\u201001466\u20102"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.11497"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010008\u20100016\u2010x"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434\u2010019\u201007969\u20106"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010021\u201002405\u20100"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010016\u20100835\u20103"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.7.1970"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005332"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab214"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102006\u2010924993"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800557"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201096088\u2010y"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10634"}],"container-title":["AGING MEDICINE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/agm2.70096","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/agm2.70096","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/agm2.70096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:16:17Z","timestamp":1783840577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/agm2.70096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/agm2.70096"],"URL":"https:\/\/doi.org\/10.1002\/agm2.70096","archive":["Portico"],"relation":{},"ISSN":["2475-0360","2475-0360"],"issn-type":[{"value":"2475-0360","type":"print"},{"value":"2475-0360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}