{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:03:37Z","timestamp":1789725817268,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":32,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hair cortisol has been increasingly used as an important biomarker of chronic stress, as it reflects prolonged systemic exposure to cortisol over time. Such exposure has been associated with alterations in body composition; however, the associations with sarcopenia and sarcopenic obesity have still received little attention in the scientific literature on aging. The study aimed to assess the association between hair cortisol, dynapenia, sarcopenia, and sarcopenic obesity in a multicenter and multiethnic Brazilian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The criterion used to classify sarcopenia was specific to the study population, and the categories used were dynapenia (reduced muscle strength), sarcopenia (reduced muscle strength and mass), and sarcopenic obesity (\u2265\u200938% body fat plus sarcopenia). Hair cortisol levels (\n                      <jats:italic>pg\/mg<\/jats:italic>\n                      ) were divided into three categories: Low (&lt;\u200940), normal (40 to 128), and high (&gt;\u2009128). Simple and multiple logistic regression analyses were used to verify the association between hair cortisol, reduced muscle strength, sarcopenia, and sarcopenic obesity. The final model was adjusted for sex, BMI, hypertension, diabetes, smoking, physical activity, and race\/ethnicity, and odds ratios (\n                      <jats:italic>OR<\/jats:italic>\n                      ) and 95% confidence intervals (\n                      <jats:italic>95% CI<\/jats:italic>\n                      ) were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 947 participants were included (aged 54 to 82\u2009years, mean age 67.1\u2009years, 63.7% women). Participants with high hair cortisol levels showed lower odds of reduced muscle strength (\n                      <jats:italic>OR: 0.796; 95% CI: 0.504\u20131.255),<\/jats:italic>\n                      suggesting an inverse association; this was not statistically significant. However, no significant association was seen between chronic stress and sarcopenia (\n                      <jats:italic>OR: 1.106; 95% CI: 0.555\u20132.206<\/jats:italic>\n                      ) or sarcopenic obesity (\n                      <jats:italic>OR: 0.607; 95% CI: 0.162\u20132.279<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a sample of Brazilian adults, hair cortisol level, a measurement technique not affected by physiological fluctuations, was not associated with reduced muscle strength, sarcopenia, or sarcopenic obesity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/agm2.70101","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T18:35:51Z","timestamp":1788374151000},"page":"384-393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Hair Cortisol, Sarcopenia, and Sarcopenic Obesity: Results From the\n                    <scp>ELSA<\/scp>\n                    \u2010Brasil Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1349-0742","authenticated-orcid":false,"given":"Christiano Barbosa","family":"da Silva","sequence":"first","affiliation":[{"name":"Sergio Arouca National School of Public Health Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3090-5444","authenticated-orcid":false,"given":"Isiyara Taverna","family":"Pimenta","sequence":"additional","affiliation":[{"name":"Sergio Arouca National School of Public Health Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6250-2036","authenticated-orcid":false,"given":"Rosane Harter","family":"Griep","sequence":"additional","affiliation":[{"name":"Laboratory of Environmental and Health Education Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8282-6521","authenticated-orcid":false,"given":"Arlinda Barbosa","family":"Moreno","sequence":"additional","affiliation":[{"name":"Sergio Arouca National School of Public Health Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-5678","authenticated-orcid":false,"given":"Isabela Judith Martins","family":"Bensenor","sequence":"additional","affiliation":[{"name":"Center for Clinical and Epidemiologic Research University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-7811","authenticated-orcid":false,"given":"Sandhi Maria","family":"Barreto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Clinical Hospital\/EBSERH Federal University of Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3837-0731","authenticated-orcid":false,"given":"Maria In\u00eas","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Federal University of Rio Grande Do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7303-0030","authenticated-orcid":false,"given":"Anissa","family":"Daliry","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Physiopathology Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5319-5513","authenticated-orcid":false,"given":"Maria de Jesus Mendes da","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Sergio Arouca National School of Public Health Oswaldo Cruz Foundation  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.11.071"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2006.8.4\/bmcewen"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010021\u201002106\u20101"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.15698\/cst2021.06.250"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.09.009"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.09.010"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.psy.0000058374.50240.bf"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2022.10.006"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201033922\u20105"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886\u2010019\u20101208\u20107"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201025143\u2010z"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1361715"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42000\u2010018\u20100023\u20107"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31138\u20109"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102\u2010311X00164917"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2019.10"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2004.52014.x"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2018.11.003"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1809\u201098232011000400017"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520\u2010025\u201002995\u20109"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2004.250"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2008.03212.x"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102265.2007.02900.x"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13497"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr294"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114522003531"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.465"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2000.tb06498.x"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2011.04.005"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362519"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201044693\u20103"},{"key":"e_1_2_14_34_1","volume-title":"Obesity: Preventing and Managing the Global Epidemic: Report of a WHO Consultation","author":"World Health Organization","year":"2000"},{"issue":"2","key":"e_1_2_14_35_1","first-page":"5","article-title":"International Physical Activity Questionnaire (IPAQ): Study of Validity and Reproducibility in Brazil","volume":"6","author":"Matsudo S.","year":"2001","journal-title":"Revista Brasileira de Atividade F\u00edsica & Sa\u00fade"},{"key":"e_1_2_14_36_1","unstructured":"International Physical Activity Questionnaire (IPAQ) Research Committee Guidelines for data processing and analysis of the International Physical Activity Questionnaire (IPAQ) \u2013 Short and Long Forms 2011Available from https:\/\/sites.google.com\/view\/ipaq\/score."},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.02.019"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab862"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10020093"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012\u20103663"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034\u20108910.2013047003889"}],"container-title":["AGING MEDICINE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/agm2.70101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/agm2.70101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/agm2.70101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T09:17:56Z","timestamp":1789723076000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/agm2.70101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/agm2.70101"],"URL":"https:\/\/doi.org\/10.1002\/agm2.70101","archive":["Portico"],"relation":{},"ISSN":["2475-0360","2475-0360"],"issn-type":[{"value":"2475-0360","type":"print"},{"value":"2475-0360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"2025-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}