{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:05:07Z","timestamp":1789725907181,"version":"4.0.1"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3605500"],"award-info":[{"award-number":["2023YFC3605500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171585"],"award-info":[{"award-number":["82171585"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Kidney function declines with aging, leading to a high prevalence of age\u2010related disease. Concurrently, the increasing prevalence of overweight and obesity may influence age\u2010related kidney changes. This study aims to clarify the relationship between body mass index (BMI) and kidney function in the Chinese population, with a focus on sex differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross\u2010sectional study involving 343,040 Chinese adults, stratified by sex and age. Glomerular filtration rate (GFR) was estimated using the CKD\u2010EPI formula based on serum creatinine. We examined trends in BMI and its distribution across age groups, as well as the patterns of estimated GFR (eGFR) decline within BMI subgroups. Multi\u2010linear and multi\u2010logistic regression analyses were used to assess the association between BMI and age\u2010related kidney function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>BMI levels and categories varied with age, exhibiting sex\u2010specific patterns. Overweight and obese individuals experienced a more pronounced decline in eGFR, except for females under 45. In males, BMI showed a negative correlation with eGFR, while females under 65 exhibited a positive association; older females showed a negative correlation. Significant risks for mildly reduced kidney function were noted in overweight or obese males and older females, with no risk identified in younger females.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A normal BMI (18.5\u201325\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) is associated with better age\u2010related kidney function in all\u2010aged males and females older than 45\u2009years, considering eGFR levels and decline rates.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/agm2.70102","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:36:02Z","timestamp":1786653362000},"page":"394-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beneficial Body Mass Index for Age\u2010Related Kidney Function in Males and Females"],"prefix":"10.1002","volume":"9","author":[{"given":"Lu","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University  Nanjing China"},{"name":"Department of Nephrology The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University  Huaian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Ma","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9696-2017","authenticated-orcid":false,"given":"Xinran","family":"Ni","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Health 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