{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:05:33Z","timestamp":1789725933406,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":35,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["262175"],"award-info":[{"award-number":["262175"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["334361"],"award-info":[{"award-number":["334361"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Understanding the molecular mechanisms of aging guides the development of prevention, intervention, and treatment strategies to reduce the incidence of common age\u2010associated diseases. Over the past decades, the proposed key features (hallmarks) of aging cells have directly or indirectly provided us clues, furthering our understanding of the causes of disease and assisting with the development of therapeutic strategies for diseases such as rare premature aging diseases like Werner syndrome and ataxia telangiectasia (A\u2010T), as well as the common age\u2010related diseases like dementia and sarcopenia. In this editorial, we take a closer look at three of these hallmarks including genomic instability, defective macroautophagy, and mitochondrial dysfunction, and the applications of these concepts in understanding the progress of complex diseases. Mounting studies from the laboratory, supported by emerging clinical evidence, point to the reduction of the oxidized form of nicotinamide adenine dinucleotide (NAD\n                    <jats:sup>+<\/jats:sup>\n                    ) as a commonality between many of these hallmarks of aging. Intriguingly, stimulating mitochondrial autophagy (mitophagy) via improvement of NAD\n                    <jats:sup>+<\/jats:sup>\n                    availability appears to be a promising and effective therapeutic strategy for many diseases relating to aging. Future studies on the hallmarks of aging should address their internal linkages and clinical interventions.\n                  <\/jats:p>","DOI":"10.1002\/agm2.70107","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:49:27Z","timestamp":1788619767000},"page":"370-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Insights Into the Mechanisms of Biological Aging That Guide Translational and Clinical Research"],"prefix":"10.1002","volume":"9","author":[{"given":"Evandro Fei","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Clinical Molecular Biology University of Oslo and Akershus University Hospital  L\u00f8renskog Norway"},{"name":"The Norwegian Centre on Healthy Ageing (NO\u2010Age) and the Norwegian National Anti\u2010Alzheimer's Disease (NO\u2010AD) Networks  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilde","family":"Nilsen","sequence":"additional","affiliation":[{"name":"The Norwegian Centre on Healthy Ageing (NO\u2010Age) and the Norwegian National Anti\u2010Alzheimer's Disease (NO\u2010AD) Networks  Oslo Norway"},{"name":"Institute of Clinical Medicine, University of Oslo  Oslo Norway"},{"name":"Centre for Embryology and Healthy Development (CRESCO) University of Oslo  Oslo Norway"},{"name":"Department of Microbiology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten","family":"Scheibye\u2010Knudsen","sequence":"additional","affiliation":[{"name":"Center for Healthy Aging, Department of Cellular and Molecular Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4823-6429","authenticated-orcid":false,"given":"Vilhelm 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