{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:50:24Z","timestamp":1791978624598,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aging Medicine"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Frailty is a geriatric syndrome associated with increased vulnerability to adverse health outcomes in older adults. Circadian rhythms regulate multiple physiological processes relevant to aging, including sleep, metabolism, and immune function; however, the relationship between circadian biology and frailty remains incompletely understood. This study aimed to examine associations between chronotype, insomnia, metabolic parameters, and peripheral clock gene expression in Mexican older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 751 community\u2010dwelling older adults were included. Chronotype was assessed using the Morningness\u2010Eveningness Questionnaire (MEQ), and associations with insomnia and metabolic parameters were evaluated using multivariate regression models. Peripheral circadian clock gene expression was analyzed in peripheral blood mononuclear cells (PBMCs) from a subsample of 82 participants using principal component analysis (PCA) and gene\u2010specific linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most participants exhibited a morning chronotype. Individuals with an extreme morning chronotype had lower odds of insomnia than those with an intermediate chronotype (adjusted\n                      <jats:italic>OR<\/jats:italic>\n                      \u2009=\u20090.393, 95%\n                      <jats:italic>CI<\/jats:italic>\n                      0.169\u20130.827,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). No significant associations between chronotype and metabolic parameters remained after adjustment for covariates and correction for multiple comparisons. PCA identified a coordinated pattern of clock gene expression, with pre\u2010frail and frail participants exhibiting lower PC1 scores than robust individuals. Gene\u2010specific analyses showed lower expression of several clock genes in pre\u2010frail and frail participants, while lower CLOCK expression remained significantly associated with pre\u2010frailty after adjustment for chronotype, insomnia, age, sex, and body mass index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this cohort of older adults, morning chronotype was associated with lower odds of insomnia, whereas frailty was associated with differences in peripheral clock gene expression measured at a morning time point. These findings support a relationship between circadian\u2010related characteristics and frailty in older adults and warrant further investigation using longitudinal and multi\u2010time\u2010point circadian assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/agm2.70117","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:05:30Z","timestamp":1791975930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronotype and Peripheral Clock Genes: Association With Frailty and Insomnia in Mexican Older Adults"],"prefix":"10.1002","author":[{"given":"Citlally E.","family":"Ortiz\u2010V\u00e1zquez","sequence":"first","affiliation":[{"name":"Facultad de Estudios Superiores Zaragoza UNAM  Mexico City Mexico"},{"name":"Unidad de Investigaci\u00f3n Epidemiol\u00f3gica y en Servicios de Salud, \u00c1rea de Envejecimiento, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5657-6442","authenticated-orcid":false,"given":"Paola","family":"Garcia\u2010delaTorre","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Epidemiol\u00f3gica y en Servicios de Salud, \u00c1rea de Envejecimiento, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5648-7223","authenticated-orcid":false,"given":"Sergio","family":"S\u00e1nchez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Epidemiol\u00f3gica y en Servicios de Salud, \u00c1rea de Envejecimiento, Centro M\u00e9dico Nacional Siglo XXI Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4473-4471","authenticated-orcid":false,"given":"Lorena","family":"Aguilar\u2010Arnal","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular y Fisiolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas UNAM  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9707-859X","authenticated-orcid":false,"given":"Luc\u00eda","family":"Mendoza\u2010Viveros","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Biolog\u00eda Molecular Instituto Potosino de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica  San Luis Potos\u00ed Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(19)31786\u20106"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148282"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44318\u2010024\u201000088\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178782"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148286"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10522\u2010025\u201010301\u20103"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.21149\/14759"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2020.03.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201042727\u2010z"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10433\u2010024\u201000804\u20102"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S139860"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"97","article-title":"A Self\u2010Assessment Questionnaire to Determine Morningness\u2010Eveningness in Human Circadian Rhythms","volume":"4","author":"Horne J. A.","year":"1976","journal-title":"International Journal of Chronobiology"},{"issue":"5","key":"e_1_2_11_14_1","article-title":"Estudio de la validaci\u00f3n de la traducci\u00f3n al espa\u00f1ol de la escala Atenas de insomnio","volume":"28","author":"Nenclares Portocarrero K.","year":"2005","journal-title":"Salud Mental"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022\u20103999(02)00604\u20109"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.m146"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2019.1641111"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.70104"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleepadvances\/zpae023"},{"issue":"6","key":"e_1_2_11_20_1","article-title":"Sleep Disorders in Older People. How Do Older People From Mexico City Sleep?","volume":"59","author":"Moreno\u2010Tamayo K.","year":"2021","journal-title":"Revista M\u00e9dica del Instituto Mexicano del Seguro Social"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S320192"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014\u20103754"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2022.101108"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.11.002"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00095"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/07420520701800736"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1606242"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00018.2020"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90328"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140\u20106736(92)92817\u2010Y"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.04.012"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1240636"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI170998"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2017.11.002"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101530"}],"container-title":["AGING MEDICINE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/agm2.70117","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/agm2.70117","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/agm2.70117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:05:31Z","timestamp":1791975931000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/agm2.70117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":34,"alternative-id":["10.1002\/agm2.70117"],"URL":"https:\/\/doi.org\/10.1002\/agm2.70117","archive":["Portico"],"relation":{},"ISSN":["2475-0360","2475-0360"],"issn-type":[{"value":"2475-0360","type":"print"},{"value":"2475-0360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2026-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"agm2.70117"}}