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Some recent studies have demonstrated that a slight dilatation of the main pancreatic duct (<jats:styled-content style=\"fixed-case\">MPD<\/jats:styled-content>) and small cystic lesions were detected initially in most cases diagnosed at an early stage. Detecting these abnormal findings in cases with high risk factors through an effective screening system including image diagnosis, some biological markers, or familial cancer registrations should contribute to early diagnosis of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>. It has been reported that endoscopic ultrasonography (<jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>) is essential for detecting tumors &lt;10\u00a0mm with a favorable prognosis. Additionally, <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content>\u2010guided fine\u2010needle aspiration biopsy is useful for confirming final histological diagnosis. For the diagnosis of stage 0 <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>, local irregular stenosis of <jats:styled-content style=\"fixed-case\">MPD<\/jats:styled-content> should be an important initial abnormal sign detected by <jats:styled-content style=\"fixed-case\">EUS<\/jats:styled-content> or magnetic resonance cholangiopancreatography. Cytodiagnosis multiple times using pancreatic juice obtained by endoscopic nasopancreatic drainage should be essential for the final diagnosis. Recently, activities of regional networks between specialist doctors in medical centers and general practitioners for early diagnosis of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> have been reported in Japan. In the future, these activities may play an important role in the early diagnosis of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>.<\/jats:p>","DOI":"10.1002\/ags3.12004","type":"journal-article","created":{"date-parts":[[2017,4,26]],"date-time":"2017-04-26T07:20:55Z","timestamp":1493191255000},"page":"44-51","source":"Crossref","is-referenced-by-count":32,"title":["Early diagnosis of pancreatic cancer: Current trends and concerns"],"prefix":"10.1002","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3196-8551","authenticated-orcid":false,"given":"Keiji","family":"Hanada","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Onomichi General Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hironobu","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Surgery Onomichi General Hospital Hiroshima 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