{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:34:55Z","timestamp":1791308095930,"version":"4.3.1"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T00:00:00Z","timestamp":1537142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      The aim of this dual\u2010center randomized controlled trial was to determine the optimal duration of antimicrobial prophylaxis in patients treated with pancreaticoduodenectomy (\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      ) who underwent preoperative biliary drainage (\n                      <jats:styled-content style=\"fixed-case\">PBD<\/jats:styled-content>\n                      ) but were without cholangitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Some reports showed that\n                      <jats:styled-content style=\"fixed-case\">PBD<\/jats:styled-content>\n                      in patients undergoing pancreatectomy increased the rate of perioperative complications. However, no clinical trial has evaluated the optimal duration of antimicrobial prophylaxis with a focus on patients who underwent\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      following\n                      <jats:styled-content style=\"fixed-case\">PBD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 82 patients who underwent\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      between March 2012 and December 2016 were randomly assigned to either a 1\u2010day group (n\u00a0=\u00a040), in which cefozopran (\n                      <jats:styled-content style=\"fixed-case\">CZOP<\/jats:styled-content>\n                      ) as antimicrobial prophylaxis was given only on the day of surgery, or a 5\u2010day group (n\u00a0=\u00a042), in which\n                      <jats:styled-content style=\"fixed-case\">CZOP<\/jats:styled-content>\n                      was given for 5 consecutive days beginning on the day of surgery. We evaluated the incidence of infectious and other complications after\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Outcomes were significantly better in the 1\u2010day group compared with the 5\u2010day group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) in terms of the incidence of overall infectious complications (15% vs 36%, respectively), intra\u2010abdominal abscess (3% vs 21%, respectively), clinically relevant postoperative pancreatic fistula (8% vs 24%, respectively), and Clavien\u2010Dindo grade\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      \u2010V complications (10% vs 31%, respectively). Duration of postoperative hospital stay was significantly shorter in the 1\u2010day group (10\u00a0days vs 15\u00a0days,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.018). Anaerobic bacteria and methicillin\u2010resistant cocci were isolated from the drainage fluid only among patients in the 5\u2010day group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Single\u2010day prophylactic use of\n                      <jats:styled-content style=\"fixed-case\">CZOP<\/jats:styled-content>\n                      is appropriate for patients who undergo\n                      <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>\n                      following\n                      <jats:styled-content style=\"fixed-case\">PBD<\/jats:styled-content>\n                      without preoperative cholangitis.\n                    <\/jats:p>\n                  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