{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:58:07Z","timestamp":1774637887949,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In Japanese patients with familial adenomatous polyposis (FAP), colectomy tends to be postponed or avoided.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to clarify the current clinical practice from a Japanese multicenter cohort study database.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the records of 250 patients with non\u2010dense FAP who did not require colorectal cancer removal. The clinical outcomes were compared between patients who received colectomy (n\u00a0=\u00a0142) (Group A) and those who did not receive colectomy (n\u00a0=\u00a0108) (Group B).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The colectomy rate based on the age at the final follow\u2010up examination was 46%, 60%, 54%, 65%, at \u226429, 30\u201339, 40\u201349, and\u2009\u2265\u200950\u2009years, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.11). The development of colorectal cancer did not differ between Groups A and B (25% vs 22% <jats:italic>P<\/jats:italic>\u00a0=\u00a0.67); however, colorectal cancer was diagnosed at the Tis stage in 88% of the patients with colorectal cancer in Group B, and 34% of the patients with colorectal cancer in Group A (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Regarding survival, all patients in Group B were alive at the final follow\u2010up examination. In contrast, six patients in Group A died, including three patients with desmoid tumors and one with colon cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over one\u2010third of patients with non\u2010dense FAP (polyps\u2009\u2264\u20091000) in Japan did not receive colectomy at &gt;30\u2009years of age, and patients who managed without colectomy showed acceptable survival with the early diagnosis of colorectal cancer, and a very low incidence of desmoid tumor development, indicating that this approach represents a potential option for the management of selected non\u2010dense FAP patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12577","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T11:10:27Z","timestamp":1653390627000},"page":"778-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Current clinical practice for familial adenomatous polyposis in Japan: A nationwide multicenter study"],"prefix":"10.1002","volume":"6","author":[{"given":"Takaaki","family":"Matsubara","sequence":"first","affiliation":[{"name":"Department of Surgery, Division of Lower Gastrointestinal Surgery Hyogo College of Medicine  Nishinomiya Hyogo Japan"},{"name":"Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5886-3138","authenticated-orcid":false,"given":"Naohito","family":"Beppu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Lower Gastrointestinal Surgery Hyogo College of Medicine  Nishinomiya Hyogo Japan"},{"name":"Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum  Tokyo 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Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Department of Gastroenterology Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhito","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Department of Surgical Oncology, Faculty of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiwamu","family":"Akagi","sequence":"additional","affiliation":[{"name":"Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Division of Molecular Diagnosis and Cancer Prevention Saitama Cancer Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Sudo","sequence":"additional","affiliation":[{"name":"Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Department of Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-1199","authenticated-orcid":false,"given":"Hideki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Study Group for Familial Adenomatous Polyposis in the Japanese Society for Cancer of the Colon and Rectum  Tokyo Japan"},{"name":"Department of Surgery National Defense Medical College  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8454-1995","authenticated-orcid":false,"given":"Tatsuro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Study Group for 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