{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:59:33Z","timestamp":1783699173217,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The purpose of this study was to investigate the relation between preoperative cachexia index (CXI) and long\u2010term outcomes in patients with colorectal liver metastases (CRLM) after hepatic resection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In all,118 patients who underwent hepatic resection for CRLM were analyzed retrospectively. The relationship between CXI and the long\u2010term outcomes in patients after hepatic resection was investigated. CXI was calculated based on preoperative skeletal muscle index, serum albumin level, and neutrophil\u2013lymphocyte ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The multivariate analysis showed that extrahepatic lesion (hazard ratio [HR] 2.86, 95% confidence interval [CI] 1.48\u20135.53, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and high CXI (HR 0.44, 95% CI 0.20\u20130.98, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) were independent and significant predictors of disease\u2010free survival. Moreover, extrahepatic lesion (HR 2.32, 95% CI 1.03\u20135.22, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04), high CXI (HR 0.17, 95% CI 0.05\u20130.57, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), and curability R 1 or 2 (HR 3.29, 95% CI 1.23\u20138.78, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) were independent and significant predictors of overall survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CXI is a useful prognostic factor for disease\u2010free survival and overall survival after hepatic resection in CRLM patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12578","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T22:48:35Z","timestamp":1652309315000},"page":"804-812","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver 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