{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T00:38:57Z","timestamp":1783989537229,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:00:00Z","timestamp":1678838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP21K08805"],"award-info":[{"award-number":["JP21K08805"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Cachexia is associated with the morbidity and mortality of cancer patients. The cachexia index (CXI) is a novel biomarker of cachexia associated with the prognosis for certain cancers. This study analyzed the relationship between CXI with long\u2010term outcomes of gastric cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 175 gastric cancer patients who underwent curative gastrectomy at our hospital between January 2011 and October 2019. The CXI was calculated using skeletal muscle index, serum albumin level, and neutrophil\u2010to\u2010lymphocyte ratio. The prognostic value of CXI was investigated by univariate and multivariate Cox hazard regression models adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the multivariate analyses, tumor location (hazard ratio [HR], 0.23; 95% confidence interval [CI], 0.11\u20130.49; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), disease stage (HR, 15.4; 95% CI, 4.18\u201356.1; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and low CXI (HR, 2.97; 95% CI, 1.01\u20138.15; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) were independent and significant predictors of disease\u2010free survival. Disease stage (HR, 9.88; 95% CI, 3.53\u201329.1; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and low CXI (HR, 4.07; 95% CI, 1.35\u201312.3; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were independent and significant predictors of overall survival. The low CXI group had a lower body mass index (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), advanced disease stage (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.034), and a lower prognostic nutritional index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cachexia index is associated with a poor prognosis for gastric cancer, suggesting the utility of comprehensive assessment using nutritional, physical, and inflammatory status.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12669","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T01:47:17Z","timestamp":1678931237000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Usefulness of the cachexia index as a prognostic indicator for patients with gastric cancer"],"prefix":"10.1002","volume":"7","author":[{"given":"Keigo","family":"Nakashima","sequence":"first","affiliation":[{"name":"Department of Surgery International University of Health and Welfare Hospital  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-3228","authenticated-orcid":false,"given":"Koichiro","family":"Haruki","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery The Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-6176","authenticated-orcid":false,"given":"Teppei","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Surgery International University of Health and Welfare Hospital  Tochigi 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