{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T18:23:43Z","timestamp":1749579823188,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The mRNA\u2010based vaccine was released as a COVID\u201019 prophylactic; however, its efficacy in organ transplant recipients is unknown. This study aimed to clarify this in liver transplant recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Herein, liver transplant recipients from two hospitals who received vaccines were included. Immunoglobulin\u2010G antibodies against the spike and nucleocapsid proteins were measured chronologically after the second, third, and fourth vaccine doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antibody levels in 125 liver transplant recipients and 20 healthy volunteers were analyzed. The median age at transplant was 35 (interquartile range 1, 53) years, and the period between transplant and the first dose was 15.2\u2009\u00b1\u20097.7\u2009years. After the second and third doses, 89.1% and 100% of recipients displayed a positive humoral response, respectively. Anti\u2010spike antibodies after the second dose were significantly reduced at 3 and 6\u2009months, compared to that at 1\u2009month (26.0 [5.4, 59.5], 14.7 [6.5, 31.4] vs. 59.7 [18.3, 164.0] AU\/mL, respectively, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). However, a booster vaccine significantly elevated anti\u2010spike antibodies in LT recipients (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) as well as in healthy controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Additionally, the decay rate was comparable between the transplant recipients and controls (2.1 [0.8, 4.5] vs. 2.7 [1.1, 4.1] AU\/mL\/day, <jats:italic>p<\/jats:italic>\u2009=\u20090.9359). Only 4.0% of vaccinated transplant recipients were positive for anti\u2010nucleocapsid antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver transplant recipients can acquire immunity similar to that of healthy people through vaccination against SARS\u2010CoV\u20102. The antibody decay rate is the same, and booster vaccinations should be administered similarly to that in healthy individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12677","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T05:07:11Z","timestamp":1681967231000},"page":"800-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antibody titer after administration of <scp>mRNA<\/scp>\u2010based vaccine against severe acute respiratory syndrome coronavirus 2 in liver transplant recipients"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-7609","authenticated-orcid":false,"given":"Atsuyoshi","family":"Mita","sequence":"first","affiliation":[{"name":"Division of Gastroenterological, Hepato\u2010Biliary\u2010Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery Shinshu University School of Medicine  Matsumoto 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Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0164-7685","authenticated-orcid":false,"given":"Koji","family":"Kubota","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological, Hepato\u2010Biliary\u2010Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery Shinshu University School of Medicine  Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2277-5347","authenticated-orcid":false,"given":"Tsuyoshi","family":"Notake","sequence":"additional","affiliation":[{"name":"Division of Gastroenterological, Hepato\u2010Biliary\u2010Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery Shinshu University School of Medicine  Matsumoto 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