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However, posthepatectomy liver failure (PHLF) remains a major cause of hepatectomy\u2010related mortality, and the accurate prediction of PHLF based on preoperative assessment of liver functional reserve is a critical issue. The definition of PHLF proposed by the International Study Group for Liver Surgery has gained acceptance as a standard grading criterion. Liver function can be estimated using a variety of parameters, including routine blood biochemical examinations, clinical scoring systems, dynamic liver function tests, liver stiffness and fibrosis markers, and imaging studies. The Child\u2013Pugh score and model for end\u2010stage liver disease scores are conventionally used for estimating liver decompensation, although the alternatively developed albumin\u2010bilirubin score shows superior performance for predicting hepatic dysfunction. Indocyanine green clearance, a dynamic liver function test mostly used in Japan and other Asian countries, serves as a quantitative estimation of liver function reserve and helps determine indications for surgical procedures according to the estimated risk of PHLF. In an attempt to improve predictive accuracy, specific evaluation of liver fibrosis and portal hypertension has gained popularity, including liver stiffness measurements using ultrasonography or magnetic resonance elastography, as well as noninvasive fibrosis markers. Imaging modalities, including Tc\u201099m\u2010labeled galactosyl serum albumin scintigraphy and gadolinium\u2010enhanced magnetic resonance imaging, are used for preoperative evaluation in combination with liver volume. This review aims to provide an overview of the usefulness of current options for the preoperative assessment of liver function in predicting PHLF.<\/jats:p>","DOI":"10.1002\/ags3.12692","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T06:06:56Z","timestamp":1684735616000},"page":"871-886","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Current status of preoperative risk assessment for posthepatectomy liver failure in patients with hepatocellular carcinoma"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9676-7235","authenticated-orcid":false,"given":"Takahiro","family":"Nishio","sequence":"first","affiliation":[{"name":"Department of Surgery, Graduate School of Medicine Kyoto University  Kyoto 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