{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:19:23Z","timestamp":1781702363880,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to clarify the significance of resection of ovarian metastases from colorectal cancer and to identify the clinicopathologic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicenter retrospective study, we evaluated data on ovarian metastases from colorectal cancer obtained from patients at 20 centers in Japan between 2000 and 2014. We examined the impact of resection on the prognosis of patients with ovarian metastases and examined prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 296 patients with ovarian metastasis. The 3\u2010y overall survival rate was 68.6% for solitary ovarian metastases. In all cases of this cohort, the 3\u2010y overall survival rates after curative resection, noncurative resection, and nonresection were 65.9%, 31.8%, and 6.1%, respectively (curative resection vs noncurative resection [<jats:italic>P &lt;<\/jats:italic>\u20090.01] and noncurative resection vs nonresection [<jats:italic>P &lt;<\/jats:italic>\u20090.01]). In the multivariate analysis of prognostic factors, tumor size of ovarian metastasis (<jats:italic>P &lt;<\/jats:italic>\u20090.01), bilateral ovarian metastasis (<jats:italic>P =<\/jats:italic>\u20090.01), peritoneal metastasis (<jats:italic>P &lt;<\/jats:italic>\u20090.01), pulmonary metastasis (<jats:italic>P =<\/jats:italic>\u20090.04), liver metastasis (<jats:italic>P &lt;<\/jats:italic>\u20090.01), and remnant of ovarian metastasis (<jats:italic>P &lt;<\/jats:italic>\u20090.01) were statistically significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prognosis after curative resection for solitary ovarian metastases was shown to be relatively favorable as Stage IV colorectal cancer. Resection of ovarian metastases, not only curative resection but also noncurative resection, confers a survival benefit. Prognostic factors were large ovarian metastases, bilateral ovarian metastases, the presence of extraovarian metastases, and remnant ovarian metastases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12740","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T05:06:28Z","timestamp":1694754388000},"page":"273-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Impact of resection for ovarian metastases from colorectal cancer and clinicopathologic analysis: A multicenter retrospective study in Japan"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8741-8992","authenticated-orcid":false,"given":"Hiroyasu","family":"Kagawa","sequence":"first","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Division of Colon and Rectal Surgery Shizuoka Cancer Center  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kinugasa","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Gastrointestinal Surgery Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5023-0985","authenticated-orcid":false,"given":"Tomohiro","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Gastroenterological Surgery Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Ohue","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Gastroenterological Surgery Osaka International Cancer Institute  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushige","family":"Kawai","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichiro","family":"Hiro","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Surgery Fujita Health University Hospital  Toyoake 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Rectum"},{"name":"Department of Gastroenterological Surgery Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-995X","authenticated-orcid":false,"given":"Koji","family":"Komori","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Takii","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Gastroenterological Surgery Niigata Cancer Center Hospital  Niigata 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Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Surgery Kurume University School of Medicine  Kurume Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heita","family":"Ozawa","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Surgery Tochigi Cancer Center  Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Toiyama","sequence":"additional","affiliation":[{"name":"Study Group for Ovary Metastasis from Colorectal Cancer by the Japanese Society for Cancer of the Colon and Rectum"},{"name":"Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences Mie University Graduate School of Medicine  Tsu 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