{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:04:41Z","timestamp":1771650281415,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T00:00:00Z","timestamp":1706313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Crohn's disease (CD)\u2010associated intestinal cancers are characterized by their high incidence, particularly at the anorectal site in the Japanese population. Accumulating evidence revealed that younger\u2010onset sporadic colorectal cancer may exhibit unique biological features. To the best of our knowledge, few previous articles reported clinicopathological features in patients with CD\u2010associated anorectal cancer (CDAAC). Therefore, we aimed to clarify the relationship between the younger onset of cancer and clinicopathological characteristics and prognosis, and the efficacy of cancer surveillance in patients with CDAAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>CD patients who had been diagnosed with intestinal cancers from 1983 to 2020 were collected from 39 Japanese institutions in this study. Of 316 patients with CD\u2010associated intestinal cancers, we analyzed 211 patients with CDAAC. We divided the patients into two groups according to the median age at cancer diagnosis (45\u2009years old).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Younger\u2010onset CDAAC (YO\u2010CDAAC) patients were significantly more likely to have a poor outcome than those with older\u2010onset CDAAC (OO\u2010CDAAC) in terms of both disease\u2010free survival (DFS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.0014) and overall survival (OS) (<jats:italic>p<\/jats:italic>\u2009=\u20090.023). Multivariate analysis showed that age under 45\u2009years old at diagnosis of cancer was one of the independent factors for poor DFS and OS (hazard ratios: 2.15, 95% confidence interval: 1.09\u20134.26, <jats:italic>p<\/jats:italic>\u2009=\u20090.028, hazard ratios: 1.95, 95% confidence interval: 1.05\u20133.60, <jats:italic>p<\/jats:italic>\u2009=\u20090.033, respectively). Patients detected via surveillance showed significantly better DFS and OS rates than symptomatic patients in YO\u2010CDAAC (<jats:italic>p<\/jats:italic>\u2009=\u20090.012 and 0.0031, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>YO\u2010CDAAC may have a poorer prognosis compared with OO\u2010CDAAC. Surveillance could be important to improve cancer prognosis, especially in young CD patients with anorectal disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12773","type":"journal-article","created":{"date-parts":[[2024,1,27]],"date-time":"2024-01-27T08:08:55Z","timestamp":1706342935000},"page":"620-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Possible poor prognosis in younger\u2010onset Crohn's disease\u2010associated anorectal cancer: A subanalysis of the Nationwide Japanese study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-4854","authenticated-orcid":false,"given":"Yoshiki","family":"Okita","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1301-3268","authenticated-orcid":false,"given":"Yuji","family":"Toiyama","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-5782","authenticated-orcid":false,"given":"Hiroki","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Division of Inflammatory Bowel Disease Hyogo Medical University  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-1680","authenticated-orcid":false,"given":"Motoi","family":"Uchino","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Division of Inflammatory Bowel Disease Hyogo Medical University  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kitaro","family":"Futami","sequence":"additional","affiliation":[{"name":"Department of Surgery Fukuoka University Chikushi Hospital  Chikushino Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kinya","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Coloproctology Tokyo Yamate Medical Center  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Ajioka","sequence":"additional","affiliation":[{"name":"Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"from the Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.31.7.800"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(93)91068-S"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90807-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010215)91:4<854::AID-CNCR1073>3.0.CO;2-Z"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-010-1402-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15229"},{"issue":"7","key":"e_1_2_10_8_1","first-page":"3761","article-title":"Current state of and problems related to cancer of the intestinal tract associated with Crohn's disease in Japan","volume":"36","author":"Higashi D","year":"2016","journal-title":"Anticancer 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