{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:20:51Z","timestamp":1747146051683,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:00:00Z","timestamp":1713744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to clarify the significance of blood culture testing in the postoperative period of pancreatoduodectomy (PD), a highly invasive surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rates of blood culture sampling and positivity were investigated for febrile episodes (FEs) in patients who underwent PD (2016\u20132021). FEs were defined as body temperature of 38.0\u00b0C or higher occurring on or after the 4th postoperative day. Fever origin was diagnosed retrospectively, and FEs were classified as pancreatic fistula (PF)\u2010related or PF\u2010unrelated FEs. Factors correlated with blood culture positivity were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 339 patients who underwent PD, 99 experienced 202 FEs. Blood culture testing was performed on 160 FEs occurring in 89 patients. The sampling and positivity rates were 79.2% and 17.5%, respectively, per episode and 89.9% and 28.1%, respectively, per patient. Thirty\u2010six FEs were classified as PF\u2010related and 124 were classified as PF\u2010unrelated FEs. The blood culture positivity rate was significantly lower in PF\u2010related vs. PF\u2010unrelated FEs (1\/36 vs. 27\/124, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.006). The blood culture positivity rate was significantly higher in patients with cholangitis, catheter\u2010related blood stream infection, and urinary tract infection than PF\u2010related FEs. Multivariate analysis showed that blood culture positivity was negatively associated with PF\u2010related FEs and positively associated with accompanying symptoms of shivering, Pitt Bacteremia Score, and preoperative biliary drainage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients who underwent PD showed relatively high blood culture positivity rates. Based on these results, it may be possible to distinguish PF\u2010related and \u2010unrelated FEs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12801","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T05:39:58Z","timestamp":1713850798000},"page":"888-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Significance of blood culture testing after pancreatoduodenectomy"],"prefix":"10.1002","volume":"8","author":[{"given":"Tsukasa","family":"Aritake","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8518-5689","authenticated-orcid":false,"given":"Seiji","family":"Natsume","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomonari","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Okuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Itoh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-995X","authenticated-orcid":false,"given":"Koji","family":"Komori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-9753","authenticated-orcid":false,"given":"Tetsuya","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery Aichi Cancer Center Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-017-3498-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2015.06.030"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002077"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2011.05.025"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2010.03.016"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313481007601035"},{"issue":"8","key":"e_1_2_9_8_1","first-page":"E134","article-title":"Blood cultures for evaluation of fever after total joint arthroplasty","volume":"38","author":"Anderson JT","year":"2009","journal-title":"Am J Orthop (Belle Mead NJ)"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2006.09.007"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-0997(1998)6:6<252::AID-IDOG6>3.0.CO;2-4"},{"issue":"9","key":"e_1_2_9_11_1","first-page":"547","article-title":"Blood cultures in febrile patients after hysterectomy. 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