{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T04:06:36Z","timestamp":1747368396848,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our study aimed to examine the characteristics of elderly patients diagnosed with ulcerative colitis\u2010associated colorectal cancer (UAC) and evaluate the impact of surgical intervention on prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1086 patients diagnosed with UAC between 1980 and 2020 were retrospectively enrolled. Data were collected through the Japanese Society for Cancer of the Colon and Rectum project. The patients were divided into two groups: 248 elderly patients in the E\u2010UAC group and 838 nonelderly patients in the NE\u2010UAC group. Patients aged &gt;65\u2009y at cancer diagnosis were considered elderly.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The recurrence rate did not differ between the two groups. Segmental resection was the only common independent risk factor for recurrence in both the E\u2010UAC and the NE\u2010UAC groups. The E\u2010UAC patients had significantly better 5\u2010y disease\u2010specific survival (DSS) than the NE\u2010UAC patients (94.7% vs 91.0%, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). There were no differences in 5\u2010y recurrence\u2010free survival (RFS; 89.3% vs 86.6%, respectively, <jats:italic>p<\/jats:italic>\u2009=\u20090.24) or overall survival (OS; 88.8% vs 89.6%, <jats:italic>p<\/jats:italic>\u2009=\u20090.50). The E\u2010UAC patients who underwent segmental resection had poorer RFS than those who underwent total proctocolectomy, but there were no significant differences in DSS or OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the elevated risk of cancer recurrence observed in the UAC patients who underwent segmental resection in both the E\u2010UAC the NE\u2010UAC groups, our findings suggested that segmental resection may be a viable alternative to total proctocolectomy in terms of survival rate for the E\u2010UAC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.12885","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:42:44Z","timestamp":1731498164000},"page":"486-495","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic value of surgical treatment in elderly patients with ulcerative colitis\u2010associated colorectal cancer: A subanalysis of a nationwide Japanese multicenter study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-3610","authenticated-orcid":false,"given":"Kinuko","family":"Nagayoshi","sequence":"first","affiliation":[{"name":"Department of Surgery and Oncology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Mizuuchi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, Graduate School of Medical Sciences Kyushu University  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Okabayashi","sequence":"additional","affiliation":[{"name":"Department of Surgery Keio University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2934-1680","authenticated-orcid":false,"given":"Motoi","family":"Uchino","sequence":"additional","affiliation":[{"name":"Department of Inflammatory Bowel Disease Surgery Hyogo Medical University  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9144-5782","authenticated-orcid":false,"given":"Hiroki","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Inflammatory Bowel Disease Surgery Hyogo Medical University  Nishinomiya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuki","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Ajioka","sequence":"additional","affiliation":[{"name":"Division of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences Niigata University  Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"from the Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32448-0"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01603-8"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.255.33"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.14263"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828029c0"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-022-01927-y"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01784-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.23922\/jarc.2019-018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-303864"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000738"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"263","article-title":"European Crohn's and colitis organisation topical review on IBD in the elderly","volume":"11","author":"Sturm A","year":"2017","journal-title":"J Crohns Colitis"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.2.167"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520801977568"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.044"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.10.035"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005339"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa196"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-021-04072-9"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu253"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-021-04913-6"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828028ca"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13721"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-019-01580-y"}],"container-title":["Annals of Gastroenterological Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ags3.12885","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T13:37:14Z","timestamp":1747316234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ags3.12885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/ags3.12885"],"URL":"https:\/\/doi.org\/10.1002\/ags3.12885","archive":["Portico"],"relation":{},"ISSN":["2475-0328","2475-0328"],"issn-type":[{"type":"print","value":"2475-0328"},{"type":"electronic","value":"2475-0328"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"2024-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}