{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:42:21Z","timestamp":1787870541536,"version":"build-2784847793"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Annals of Gastroent Surgery"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to determine the cutoff values of C\u2010reactive protein (CRP) on postoperative day 3 to predict poor overall survival (OS) in men and women with gastric cancer after radical gastrectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study included consecutive patients who underwent radical gastrectomy for primary pStages I\u2013III gastric cancer between May 2006 and March 2017. The patients were randomly divided 6:4 into a training set, which examined the cutoff values for CRP, and a validation set, which validated the cutoff values. Patients with a CRP level higher than the cutoff value were defined as the high\u2010CRP group, and those with a CRP level lower than the cutoff value were defined as the low\u2010CRP group. We compared the OS of the high and low CRP groups using the log\u2010rank test and identified prognostic factors using Cox proportional hazards regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We examined the cutoff values of CRP, which were 19.1\u2009mg\/dL for men and 8.1\u2009mg\/dL for women. The median follow\u2010up duration was 66\u2009months. The high\u2010CRP group had poorer OS than the low\u2010CRP group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Multivariate analyses showed that a high CRP level was an independent poor prognostic factor for OS in all patients (hazard ratio, 1.356; 95% confidence interval, 1.168\u20131.576; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), not only in patients without postoperative complications (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) but also in patients with postoperative complications (<jats:italic>p<\/jats:italic>\u2009=\u20090.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrated that a high postoperative CRP was an independent poor prognostic factor for OS in patients with gastric cancer after radical gastrectomy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ags3.70006","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T04:12:35Z","timestamp":1741752755000},"page":"698-710","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic impact of postoperative fixed\u2010point inflammation in patients with gastric cancer after curative gastrectomy: A validation cohort study"],"prefix":"10.1002","volume":"9","author":[{"given":"Ryota","family":"Matsui","sequence":"first","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer Institute Hospital of Japanese Foundation for Cancer Research  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7417-3682","authenticated-orcid":false,"given":"Manabu","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery The Cancer 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